Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

559 questions · 576 findings · 177 reviews

No studies found 140 · 24.3%GRADE not reported 45 · 7.8%Very low 184 · 31.9%Low 131 · 22.7%Moderate 60 · 10.4%High 16 · 2.8%

Lifestyle vs control ‐ Neonatal and later outcomes

Perinatal (fetal and neonatal death) and later infant mortality · women with gestational diabetes mellitus

Lifestyle showed no clear difference in perinatal (fetal and neonatal death) and later infant mortality compared with control ‐ Neonatal and later outcomes (low certainty).

1 finding from 1 review

Plastic wrap or bag vs usual care

Mortality (death within hospital stay or at 6 months' corrected gestation) · preterm or low birth weight infants

Plastic wrap or bag showed no clear difference in mortality (death within hospital stay or at 6 months' corrected… compared with routine care (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality measured by mortality rates including failure‐to‐rescuerates (3a) Stillbirth · Adults (and/or family members) with potential for acute life‐threatening illness

The intervention probably leads to lower mortality measured by mortality rates including… (moderate certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Infant Mortality at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to lower infant Mortality at 6 months among those whose HIV diagnostic… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Infant Mortality at 12 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks probably leads to lower infant Mortality at 12 months among those whose HIV diagnostic… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV regimen administered to infants for 14 weeks probably leads to lower infant Mortality at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1 week) (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in infant Mortality at 9 months among those whose HIV diagnostic… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 14 weeks showed no clear difference in infant Mortality at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1week) (moderate certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

Infant mortality at 6 months among all those whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months may leads to lower infant mortality at 6 months among all those whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

Intervention not reported

Mortality in patients with pre‐existing renal impairment As reported in the included trials Folliow‐up: 7 days · patients with pre‐existing renal impairment

It is very uncertain whether the intervention changes mortality in patients with pre‐existing renal impairment As reported… (very low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

Infant mortality at 12 months among all those whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in infant mortality at 12 months among all those whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review