Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

35 questions · 36 findings · 20 reviews

No studies found 7 · 19.4%GRADE not reported 2 · 5.6%Very low 6 · 16.7%Low 12 · 33.3%Moderate 8 · 22.2%High 1 · 2.8%

Supervised exercise therapy following vascular intervention vs vascular intervention alone

All‐cause mortality · people with symptomatic peripheral arterial disease§

It is very uncertain whether supervised exercise therapy following vascular intervention changes mortality compared with vascular intervention alone (very low certainty).

1 finding from 1 review

Tenofovir‐based antiviral combination regimens vs placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens

All‐cause infant mortality at longest · HIV‐positive pregnant women co‐infected with hepatitis B virus

It is very uncertain whether tenofovir‐based antiviral combination regimens changes all‐cause infant mortality at longest compared with placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Mortality Number of deaths at maximum · participants with unresectable hepatocellular carcinoma

External beam radiotherapy (EBRT) plus transarterial… may leads to lower all‐cause mortality (at maximum 1‐year compared with TACE alone (low certainty).

1 finding from 1 review

Topical prophylaxis vs no topical prophylaxis

Overall mortality ‐ topical plus systemic prophylaxis versus systemic prophylaxis alone · adults receiving mechanical ventilation for at least 48 hours

Topical prophylaxis showed no clear difference in overall mortality ‐ topical plus systemic prophylaxis versus… compared with no topical prophylaxis (low certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

All‐cause mortality1 · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in all‐cause mortality1 compared with standard testing alone (moderate certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

Cancer‐related mortality at maximal · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in cancer‐related mortality3 compared with standard testing alone (moderate certainty).

1 finding from 1 review