Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

398 questions · 434 findings · 166 reviews

No studies found 95 · 21.9%GRADE not reported 31 · 7.1%Very low 91 · 21%Low 110 · 25.3%Moderate 78 · 18%High 29 · 6.7%

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Late neonatal mortality ‐ Group counselling · developing countries

It is very uncertain whether community health educational one‐to‐one and group and both… changes late neonatal mortality ‐ Group counselling compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Neonatal mortality ‐ One‐to‐one counselling · developing countries

It is very uncertain whether community health educational one‐to‐one and group and both… changes neonatal mortality ‐ One‐to‐one counselling compared with control (very low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ first dose and referral · neonates with sepsis

Comparison 1: referral or full course of antibiotics may leads to lower neonatal mortality ‐ first dose and referral compared with standard care (low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Perinatal mortality ‐ One‐to‐one counselling · developing countries

It is very uncertain whether community health educational one‐to‐one and group and both… changes perinatal mortality ‐ One‐to‐one counselling compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Group counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to lower early neonatal mortality ‐ Group counselling compared with control (low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ One‐to‐one counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to higher early neonatal mortality ‐ One‐to‐one counselling compared with control (low certainty).

1 finding from 1 review

Summary of findings table ‐ LSSS intervention vs regular salt

Stroke mortality (events per 100,000 person‐years) · Adults (general population)

It is very uncertain whether summary of findings table ‐ LSSS intervention changes stroke mortality (events per 100,000 person‐years) compared with regular salt (very low certainty).

1 finding from 1 review

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ oral + injectable antibiotics · neonates with sepsis

Comparison 1: route of antibiotic showed no clear difference in neonatal mortality ‐ oral + injectable antibiotics compared with standard care (moderate certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Mortality (in‐hospital death and 30‐day mortality) · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in mortality (in‐hospital death and 30‐day mortality) compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review

Advanced haemodynamic monitoring vs protocol using standard measures such

All‐cause mortality Advanced haemodynamic monitoring · patients with proximal femoral fracture

It is very uncertain whether advanced haemodynamic monitoring changes all‐cause mortality Advanced haemodynamic monitoring compared with protocol using standard measures such (very low certainty).

1 finding from 1 review

Dopamine‐milrinone vs dopamine‐dobutamine

All‐cause short‐term mortality: at intensive care unit · adults with cardiogenic shock

It is very uncertain whether dopamine‐milrinone changes all‐cause short‐term mortality: at intensive care unit compared with dopamine‐dobutamine (very low certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Neonatal mortality ‐ Intervention given to mothers only · developing countries

It is very uncertain whether community health educational intervention for family members and… changes neonatal mortality ‐ Intervention given to mothers only compared with control (very low certainty).

1 finding from 1 review