Findings

What do systematic reviews say?

5 questions · 6 findings · 6 reviews · Gynaecology and Fertility

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 33.3%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%

Miscarriage · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 0.86 [0.56, 1.32]
8 studies · 821 participants
Low
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.08 [0.5, 2.35]
4 studies · 748 participants
Low

Miscarriage · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

1 finding from 1 review

Miscarriage · Women undergoing IVF/ICSI cycles

It is very uncertain whether glucocorticoid supplementation changes miscarriage rate per woman compared with placebo (very low certainty).

1 finding from 1 review

Glucocorticoid supplementation during ovarian stimulation for IVF or ICSI 2017 · Cochrane Headline outcomes only
OR 1 [0.05, 18.57]
1 study · 20 participants
Very low

Miscarriage · women with subfertility

Low‐dose aspirin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

1 finding from 1 review

Aspirin for in vitro fertilisation 2016 · Cochrane Headline outcomes only
RR 1.1 [0.68, 1.77]
5 studies · 1497 participants
Low

Miscarriage · Subfertile women undergoing assisted reproduction

It is very uncertain whether G‐CSF changes miscarriage rate per woman randomised compared with no treatment or placebo (very low certainty).

1 finding from 1 review