Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

27 questions · 29 findings · 8 reviews · Gynaecology and Fertility

No studies found 2 · 6.9%GRADE not reported 0 · 0%Very low 14 · 48.3%Low 12 · 41.4%Moderate 0 · 0%High 1 · 3.4%

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Miscarriage · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts showed no clear difference in miscarriage rate per pregnancy compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Short interval vs long interval

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether short interval changes miscarriage rate per pregnancy ‐ 24 hours versus 34 to 36 hours compared with long interval (very low certainty).

3 findings from 1 review

hCG vs no ovulation trigger

Miscarriage per clinical pregnancy · women with anovulatory infertility undergoing ovulation induction with clomiphene citrate

Human chorionic gonadotrophin showed no clear difference in miscarriage rate per clinical pregnancy Spontaneous pregnancy loss… compared with no ovulation trigger (low certainty).

1 finding from 1 review

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Miscarriage · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

It is very uncertain whether starting administration of the progestogen earlier changes miscarriage Rate compared with starting administration of the progestogen later (very low certainty).

1 finding from 1 review