Findings

What do systematic reviews say?

5 questions · 5 findings · 4 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 3 · 60%Moderate 1 · 20%High 0 · 0%

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Miscarriage · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
odds ratio 2.14 [0.93, 4.95]
2 studies · 282 participants
Low

Single vs multiple embryo transfer

Miscarriage · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Single showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
odds ratio 0.96 [0.66, 1.42]
7 studies · 1560 participants
Low

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Miscarriage · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

Day 3 showed no clear difference in miscarriage rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

1 finding from 1 review

Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
RR 1.16 [0.84, 1.6]
9 studies · 2153 participants
Moderate

GnRHa depot vs GnRHa daily injection

Miscarriage · women undergoing pituitary suppression in assisted reproduction

GnRHa depot showed no clear difference in miscarriage rates compared with gnRHa daily injection (low certainty).

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
OR 1.16 [0.7, 1.94]
9 studies · 512 participants
Low

Assisted hatching vs no assisted hatching

Miscarriage · women undergoing assisted reproduction

It is very uncertain whether assisted hatching changes miscarriage rate per woman randomised compared with no assisted hatching (very low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.13 [0.82, 1.56]
17 studies · 2810 participants
Very low