What do systematic reviews say?

Cryopreservation vs fresh embryos transfer

Cryopreservation showed no clear difference in number of livebirths (livebirth rate) compared with fresh embryos transfer (low certainty).

• Embryo freezing for preventing ovarian hyperstimulation syndrome 2007 · Cochrane Headline outcomes only
  OR 1.03 [0.5, 2.12]
  1 study · 125 participants
  Low

Analysis 7 ‐ Collagen membrane with polyethylene glycol and glycerol vs Ringer's lactate

The review found no eligible studies for this question.

• Barrier agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metabolomics vs non metabolomics

Metabolomics showed no clear difference in live birth rate or ongoing pregnancy (Delivery of a live fetus after… compared with non metabolomics (low certainty).

• Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies 2018 · Cochrane Headline outcomes only
  OR 1.02 [0.77, 1.35]
  4 studies · 924 participants
  Low

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in live birth rate/ongoing pregnancy compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 0.97 [0.58, 1.64]
  2 studies · 485 participants
  Low

Progesterone vs no treatment or placebo (route of progesterone administration)

Progesterone showed no clear difference in live birth/ongoing pregnancy rate compared with no treatment or placebo (route of progesterone administration) (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 1.1 [0.81, 1.48]
  7 studies · 1792 participants
  Low

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in live birth rate/ongoing pregnancy rate compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 1.24 [0.8, 1.92]
  4 studies · 1054 participants
  Low

Monopolar resectoscope vs bipolar resectoscope

It is very uncertain whether monopolar resectoscope changes live birth rate/ ongoing pregnancy ratea compared with bipolar resectoscope (very low certainty).

• Surgical treatment of fibroids for subfertility 2020 · Cochrane Headline outcomes only
  OR 0.86 [0.3, 2.5]
  1 study · 68 participants
  Very low

DHEA or testosterone vs placebo/no treatment

DHEA or testosterone probably leads to higher live birth/ongoing pregnancy rate ‐ DHEA compared with placebo/no treatment (moderate certainty).

• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 1.81 [1.25, 2.62]
  8 studies · 878 participants
  Moderate
• Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
  OR 2.6 [1.3, 5.2]
  4 studies · 345 participants
  Moderate

RhCG vs uhCG

RhCG showed no clear difference in ongoing pregnancy/live birth rate per woman compared with uhCG (moderate certainty).

• Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
  OR 1.15 [0.89, 1.49]
  7 studies · 1136 participants
  Moderate

RhLH vs uhCG

It is very uncertain whether rhLH changes ongoing pregnancy/live birth rate per woman compared with uhCG (very low certainty).

• Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
  OR 0.95 [0.51, 1.78]
  2 studies · 289 participants
  Very low

GnRHa depot vs GnRHa daily injection

GnRHa depot showed no clear difference in live birth/ongoing pregnancy rate per woman Delivery of one or more… compared with gnRHa daily injection (low certainty).

• Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
  OR 0.95 [0.7, 1.31]
  7 studies · 873 participants
  Low

Summary of findings table ‐ Progestogens vs Progestogen 2

• Progestogens for prevention of luteinising hormone (LH) surge in women undergoing controlled ovarian hyperstimulation… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2 participants
  GRADE not reported

Dopamine agonist vs other active intervention

Dopamine agonist showed no clear difference in live birth rate compared with other active intervention (low certainty).

• Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes only
  OR 1.08 [0.73, 1.59]
  2 studies · 430 participants
  Low

Dopamine agonist vs placebo or no intervention

Dopamine agonist showed no clear difference in live birth rate compared with placebo/no intervention (low certainty).

• Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes only
  OR 0.96 [0.6, 1.55]
  3 studies · 362 participants
  Low

Dopamine agonist plus co‐intervention vs co‐intervention

Dopamine agonist plus co‐intervention showed no clear difference in live birth rate compared with co‐intervention (low certainty).

• Dopamine agonists for preventing ovarian hyperstimulation syndrome 2021 · Cochrane Headline outcomes only
  OR 1.21 [0.81, 1.8]
  2 studies · 400 participants
  Low

Gore‐Tex vs oxidised regenerated cellulose

The review found no eligible studies for this question.

• Barrier agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Analysis 1 ‐ Oxidised regenerated cellulose vs no treatment at laparoscopy

The review found no eligible studies for this question.

• Barrier agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Analysis 1 ‐ Oxidised regenerated cellulose vs no treatment at laparotomy

The review found no eligible studies for this question.

• Barrier agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Gel agents vs hydroflotation agents used

The review found no eligible studies for this question.

• Fluid and pharmacological agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hydroflotation agents vs no hydroflotation agents (or placebo)

Hydroflotation agents showed no clear difference in live birth rate compared with no hydroflotation agents (or placebo) (low certainty).

• Fluid and pharmacological agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes only
  OR 0.67 [0.29, 1.58]
  2 studies · 208 participants
  Low