Findings

What do systematic reviews say?

24 questions · 24 findings · 15 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 20.8%Low 7 · 29.2%Moderate 5 · 20.8%High 7 · 29.2%

ICU follow‐up services vs standard care or no follow‐up service

Health‐related quality of life (HRQoL) · adult survivors of the ICU, excluding those already in an existing follow‐up or rehabilitation programme

1 finding from 1 review

Follow‐up services for improving long‐term outcomes in intensive care unit (ICU) survivors 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 286 participants
Low

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Health‐related quality of life ‐ anxiety Time point: 10 months to 5 years from randomisation Measured by different scales · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in health‐related quality of life ‐ anxiety Time point: 10 months to 5… compared with no LDCT screening (low certainty).

1 finding from 1 review

Impact of low‐dose computed tomography (LDCT) screening on lung cancer‐related mortality 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 8153 participants
Low

Low glycaemic index (GI) or glycaemic load (GL) diets vs higher GI or GL diets

Health‐related quality of life Scale · Adults or children with overweight or obesity

1 finding from 1 review

Low glycaemic index or low glycaemic load diets for people with overweight or obesity 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Very low

Balneotherapy vs no treatment

Health‐related quality of life –CIVIQ2 Scale: 20–100 · people with chronic venous insufficiency

1 finding from 1 review

Balneotherapy for chronic venous insufficiency 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 153 participants
Very low

Mepolizumab intravenous (IV) vs placebo

Health‐related quality of life (ACQ) Scale from: 0 to 6 (lower is better) · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 369 participants
High

Mepolizumab subcutaneous (SC) vs placebo

Health‐related quality of life (ACQ) Scale from: 0 to 6 (lower is better) · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1231 participants
High

Benralizumab subcutaneous (SC) vs placebo

Health‐related quality of life (ACQ) Scale from: 0 to 6 (lower is better) · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 2791 participants
High

Reslizumab intravenous (IV) vs placebo

Health‐related quality of life (ACQ) Scale from: 0 to 6 (lower is better) · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1652 participants
High

Reslizumab subcutaneous (SC) vs placebo

Health‐related quality of life (ACQ) Scale from: 0 to 6 (lower is better) · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 464 participants
High

Mepolizumab subcutaneous (SC) vs placebo

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1231 participants
High

Reslizumab subcutaneous (SC) vs placebo

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · people with asthma

1 finding from 1 review

Anti‐IL‐5 therapies for asthma 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 464 participants
High

Summary of findings ‐ Inhaled mannitol vs placebo

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · people with bronchiectasis

Inhaled mannitol showed no clear difference in health‐related quality of life measured on the SGRQ Scale from 0 to… compared with placebo (moderate certainty).

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 840 participants
Moderate

Mepolizumab 100 mg vs placebo

Change in SGRQ total score · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1285 participants
Moderate

Mepolizumab 300 mg vs placebo

QoL · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 451 participants
Moderate

Mepolizumab 100 mg vs placebo

QoL · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 911 participants
Moderate

Mucolytic vs placebo

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · chronic bronchitis or COPD

1 finding from 1 review

Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 2721 participants
Moderate

Cognitive‐behavioural intervention vs controls

Health‐related quality of life end of treatment (0‐80 scale) Higher scores indicate lower health‐related quality of life · patients with fibromyalgia

1 finding from 1 review

Cognitive behavioural therapies for fibromyalgia 2013 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 1238 participants
Low

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Self‐reported health‐related quality of life (0‐100 scale) Higher scores indicate higher burden of disease (lower quality of life) · patients with fibromyalgia

Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported health‐related quality of life (0‐100 scale) Higher… compared with placebo (low certainty).

1 finding from 1 review

Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia 2018 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 6861 participants
Low

Information or education intervention vs no education

Health‐related quality of life (HRQoL) · adult ICU patients and their carers

1 finding from 1 review

Information or education interventions for adult intensive care unit (ICU) patients and their carers 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 143 participants
Very low

Pursed lip breathing vs no breathing exercises

Health‐related quality of life Dyspnoea domain of Hiratsuka scale Scores range from 0 to 100, with lower scores indicating less shortness of breath · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Breathing exercises for chronic obstructive pulmonary disease 2012 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 60 participants
Low