What do systematic reviews say?

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

The review found no eligible studies for this question.

• Metformin and second‐ or third‐generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ Oral classical immunosuppressants (betamethasone) vs oral classical immunosuppressants (azathioprine, methotrexate, prednisolone)

The review found no eligible studies for this question.

• Treatments for alopecia areata: a network meta‐analysis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs megestrol

The review found no eligible studies for this question.

• Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ Metformin + megestrol vs megestrol

The review found no eligible studies for this question.

• Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Rituximab (2 x 1000 mg) plus methotrexate vs methotrexate

Rituximab (2 x 1000 mg) plus methotrexate leads to higher health‐related quality of life compared with methotrexate monotherapy (high certainty).

• Rituximab for rheumatoid arthritis 2015 · Cochrane Headline outcomes only
  RR 2 [1.1, 3.4]
  4 studies · 1526 participants
  High

Thrombopoietin mimetics vs placebo

The review found no eligible studies for this question.

• Thrombopoietin mimetics for patients with myelodysplastic syndromes 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Methotrexate vs other DMARDs

The review found no eligible studies for this question.

• Methotrexate for psoriatic arthritis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Methotrexate vs placebo

The review found no eligible studies for this question.

• Methotrexate for psoriatic arthritis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

The review found no eligible studies for this question.

• Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs sulphonylureas

The review found no eligible studies for this question.

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs thiazolidinediones

The review found no eligible studies for this question.

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs dipeptidyl‐peptidase 4 inhibitors

The review found no eligible studies for this question.

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs glucagon like peptide‐1 analogues

The review found no eligible studies for this question.

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs meglitinides

The review found no eligible studies for this question.

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Grommets vs active monitoring

• Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 85 participants
  Low

Summary of findings table ‐ Intralesional classical immunosuppresants (betamethasone or triamcinolone) vs placebo

The review found no eligible studies for this question.

• Treatments for alopecia areata: a network meta‐analysis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Methods of enhancing vision vs no treatment or waiting list

The review found no eligible studies for this question.

• Low vision rehabilitation for better quality of life in visually impaired adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Methotrexate plus ursodeoxycholic acid (UDCA) vs UDCA

The review found no eligible studies for this question.

• Pharmacological interventions for primary biliary cholangitis 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Methods of enhancing vision and/or group programmes vs active control

• Low vision rehabilitation for better quality of life in visually impaired adults 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 443 participants
  Very low

Metformin vs insulin

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 91 participants
  Very low