Findings

What do systematic reviews say?

8 questions · 8 findings · 2 reviews

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No studies found 2 · 25%GRADE not reported 0 · 0%Very low 4 · 50%Low 1 · 12.5%Moderate 1 · 12.5%High 0 · 0%

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

Endoscopic recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease

Intensification of prophylactic therapy guided by colonoscopy may leads to lower endoscopic recurrence ( compared with intensification guided by clinical recurrence (low certainty).

1 finding from 1 review

Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease 2020 · Cochrane Headline outcomes only
RR 0.73 [0.56, 0.95]
1 study · 174 participants
Low

High dose 5‐ASA vs low dose 5‐ASA

Endoscopic recurrence · people with surgically‐induced remission in Crohn's disease

High dose 5‐ASA showed no clear difference in endoscopic recurrence compared with low dose 5‐ASA (moderate certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
RR 0.79 [0.6, 1.04]
1 study · 206 participants
Moderate

5‐ASA vs no treatment

Endoscopic recurrence · people with surgically‐induced remission in Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

5‐ASA vs purine antimetabolites

Endoscopic recurrence · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether 5‐ASA changes endoscopic recurrence compared with purine antimetabolites (very low certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
RR 1.29 [0.86, 1.94]
1 study · 35 participants
Very low

5‐ASA vs anti TNF‐ɑ

Endoscopic recurrence · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether 5‐ASAs changes endoscopic recurrence compared with anti TNF‐ɑ (very low certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
RR 13.33 [1.98, 89.95]
1 study · 34 participants
Very low

Sulphasalazine vs placebo

Endoscopic recurrence · people with surgically‐induced remission in Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

5‐ASA vs placebo

Endoscopic recurrence · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether 5‐ASAs changes endoscopic recurrence compared with placebo (very low certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
RR 0.83 [0.56, 1.24]
3 studies · 537 participants
Very low

Initiation of prophylactic therapy guided by colonoscopy vs initiation of prophylactic therapy immediately after surgery

Endoscopic recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease

It is very uncertain whether initiation of prophylactic therapy guided by colonoscopy changes endoscopic recurrence (at week 102) compared with initiation of prophylactic therapy immediately after surgery (very low certainty).

1 finding from 1 review

Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease 2020 · Cochrane Headline outcomes only
RR 1.16 [0.73, 1.84]
1 study · 63 participants
Very low