Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 23 findings · 5 reviews · Headline outcomes only

No studies found 5 · 21.7%GRADE not reported 1 · 4.3%Very low 6 · 26.1%Low 3 · 13%Moderate 8 · 34.8%High 0 · 0%

Comparison 1: community‐based antibiotic delivery vs usual care

Early neonatal mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery probably leads to lower early neonatal mortality compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Community health educational interventions vs control

Early neonatal mortality · developing countries

It is very uncertain whether community health educational interventions changes early neonatal mortality compared with control (very low certainty).

2 findings from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality ‐ physician · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme showed no clear difference in early neonatal mortality ‐ physician compared with basic resuscitation training (low certainty).

1 finding from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality ‐ nurse/midwife · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme showed no clear difference in early neonatal mortality ‐ nurse/midwife compared with basic resuscitation training (moderate certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Group counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to lower early neonatal mortality ‐ Group counselling compared with control (low certainty).

1 finding from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality ‐ family/unattended · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme probably leads to lower early neonatal mortality ‐ family/unattended compared with basic resuscitation training (moderate certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ One‐to‐one counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to higher early neonatal mortality ‐ One‐to‐one counselling compared with control (low certainty).

1 finding from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality ‐ traditional birth attendants · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme probably leads to lower early neonatal mortality ‐ traditional birth attendants compared with basic resuscitation training (moderate certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Early neonatal mortality ‐ Intervention given to mothers only · developing countries

It is very uncertain whether community health educational intervention for family members and… changes early neonatal mortality ‐ Intervention given to mothers only compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Both one‐to‐one and group counselling · developing countries

Community health educational one‐to‐one and group and both… probably leads to lower early neonatal mortality ‐ Both one‐to‐one and group counselling compared with control (moderate certainty).

1 finding from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme showed no clear difference in early neonatal mortality (mortality in the first 7 days of life) compared with basic resuscitation training (moderate certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during ANC period only · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes early neonatal mortality ‐ Education provided during ANC period only compared with control (very low certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during PNC period only · developing countries

Community health educational ANC period and PNC period and both… showed no clear difference in early neonatal mortality ‐ Education provided during PNC period only compared with control (moderate certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Early neonatal mortality ‐ Intervention given to mothers and family members · developing countries

It is very uncertain whether community health educational intervention for family members and… changes early neonatal mortality ‐ Intervention given to mothers and family… compared with control (very low certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during both ANC and PNC periods · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes early neonatal mortality ‐ Education provided during both ANC and… compared with control (very low certainty).

1 finding from 1 review