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What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 3 reviews · Common Mental Disorders

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No studies found 0 · 0%GRADE not reported 1 · 20%Very low 2 · 40%Low 0 · 0%Moderate 2 · 40%High 0 · 0%

Vortioxetine vs SNRIs

Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder

It is very uncertain whether vortioxetine changes drop‐out due to adverse events compared with SNRIs (very low certainty).

1 finding from 1 review

Vortioxetine vs placebo

Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder

Vortioxetine probably leads to higher drop‐out due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Amitriptyline vs placebo

Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder

Amitriptyline probably leads to higher overall tolerability Drop‐out due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

acceptability ‐ drop‐outs due to adverse events: post‐intervention · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes acceptability ‐ drop‐outs due to adverse events: post‐intervention compared with placebo (very low certainty).

1 finding from 1 review