Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews · Neonatal

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%

Early vs late continuous positive airway pressure (CPAP)

Failure of treatment ‐ death or intermittent positive‐pressure ventilation (IPPV) before hospital discharge · preterm infants with respiratory distress for initial respiratory support

The review found no eligible studies for this question.

1 finding from 1 review

Early versus delayed continuous positive airway pressure (CPAP) for respiratory distress in preterm infants 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HFNC vs continuous positive airway pressure (CPAP)

Mortality before hospital discharge · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.78 [0.44, 1.39]
9 studies · 2009 participants
Low

HFNC vs nasal intermittent positive pressure ventilation

Mortality before hospital discharge · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) compared with nasal intermittent positive pressure ventilation (low certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.78 [0.36, 1.69]
3 studies · 254 participants
Low

HFNC vs continuous positive airway pressure (CPAP)

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) or BPD(supplemental… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 1.09 [0.74, 1.6]
7 studies · 1830 participants
Low

HFNC vs nasal intermittent positive pressure ventilation

It is very uncertain whether nasal high flow changes death (before hospital discharge) or BPD (supplemental… compared with nasal intermittent positive pressure ventilation (very low certainty).

1 finding from 1 review

Nasal high flow therapy for primary respiratory support in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.64 [0.3, 1.37]
2 studies · 182 participants
Very low

Volume‐targeted vs pressure‐limited ventilation: additional findings

Mortality before hospital discharge · neonates up to 44 weeks' postmenstrual age

Volume‐targeted showed no clear difference in death before discharge from hospital compared with pressure‐limited ventilation: main findings (low certainty).

1 finding from 1 review

Volume‐targeted versus pressure‐limited ventilation in neonates 2017 · Cochrane Headline outcomes only
RR 0.75 [0.53, 1.07]
11 studies · 771 participants
Low