What do systematic reviews say?

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

It is very uncertain whether summary of Findings Table ‐ Low changes death or BPD at 36 weeks PMA compared with moderate‐high nasal continuous positive airway pressure levels (very low certainty).

• Nasal continuous positive airway pressure levels for the prevention of morbidity and mortality in preterm infants 2021 · Cochrane Headline outcomes only
  RR 1.02 [0.56, 1.85]
  1 study · 271 participants
  Very low

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

It is very uncertain whether summary of Findings Table ‐ Low changes death or BPD at 36 weeks' PMA compared with moderate‐high nasal continuous positive airway pressure levels (very low certainty).

• Nasal continuous positive airway pressure levels for the prevention of morbidity and mortality in preterm infants 2021 · Cochrane Headline outcomes only
  RR 0.87 [0.51, 1.49]
  1 study · 93 participants
  Very low

HFNC vs low flow nasal cannula (LFNC)

• High flow nasal cannula for respiratory support in term infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 95 participants
  GRADE not reported

HFNC vs continuous positive airway pressure (CPAP)

• High flow nasal cannula for respiratory support in term infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 439 participants
  GRADE not reported

Summary of findings table for oral immunoglobulin vs control

It is very uncertain whether summary of findings table for oral immunoglobulin changes NEC‐related deaths during study period compared with control (very low certainty).

• Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates 2016 · Cochrane Headline outcomes only
  RR 1.1 [0.47, 2.59]
  3 studies · 1840 participants
  Very low