Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 18 findings · 7 reviews · Heart

No studies found 2 · 11.1%GRADE not reported 0 · 0%Very low 5 · 27.8%Low 3 · 16.7%Moderate 6 · 33.3%High 2 · 11.1%

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Mediterranean dietary intervention vs another dietary intervention

Total cardiac endpoints (all‐cause and cardiac deaths, myocardial infarction, hospital admissions for heart failure, unstable angina or stroke, unadjusted) · adults with established cardiovascular disease

It is very uncertain whether mediterranean dietary intervention changes total cardiac endpoints (all‐cause and cardiac deaths, myocardial… compared with another dietary intervention (very low certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Total mortalityDeaths · patients with coronary heart disease

Psychological intervention with or without other rehabilitation showed no clear difference in total mortalityDeaths compared with control (usual care/other rehabilitation) (moderate certainty).

1 finding from 1 review

Psychological intervention with or without other rehabilitation vs control (usual care/other rehabilitation)

Cardiac mortalityDeaths · patients with coronary heart disease

Psychological intervention with or without other rehabilitation may leads to lower cardiac mortalityDeaths compared with control (usual care/other rehabilitation) (low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in death by any cause compared with placebo or standard care (high certainty).

1 finding from 1 review

Transradial vs transfemoral approach

Short‐term cardiac death · people with coronary artery disease undergoing diagnostic coronary angiography and percutaneous coronary intervention

Transradial probably leads to lower short‐term cardiac death compared with transfemoral approach (moderate certainty).

1 finding from 1 review

Xiongshao capsule (XSC) plus conventional western medicine (CWM) vs conventional western medicine (CWM) plus placebo

All‐cause death: not measured · patients with restenosis after percutaneous coronary intervention in coronary heart disease

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics vs placebo or no intervention

Sudden cardiac death · patients with coronary heart disease

Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review