Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

222 questions · 224 findings · 82 reviews

No studies found 49 · 21.9%GRADE not reported 16 · 7.1%Very low 57 · 25.4%Low 57 · 25.4%Moderate 36 · 16.1%High 9 · 4%

Acetaminophen plus Diphenhydramine vs placebo

Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine led to lower death ‐ not reported compared with placebo; GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Death ‐ not reported · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine led to lower death ‐ not reported compared with placebo (Unit of randomisation: transfusion); GRADE not reported.

1 finding from 1 review

Intervention not reported

Death from all causes · HIV‐negative people with tuberculous pericarditis

The intervention showed no clear difference in death from all causes (low certainty).

1 finding from 1 review

Intervention not reported

Death from all causes · HIV‐positive people with tuberculous pericarditis. Most patients (80%) not on antiretroviral drugs

It is very uncertain whether the intervention changes death from all causes (very low certainty).

1 finding from 1 review

Primary‐level worker‐led collaborative care vs usual care

Adverse events ‐ death · adults with common mental disorders

It is very uncertain whether primary‐level worker‐led collaborative care changes adverse events ‐ death compared with usual care (very low certainty).

1 finding from 1 review

Intervention not reported

Death from pericarditis · HIV‐negative people with tuberculous pericarditis

The intervention probably leads to lower death from pericarditis (moderate certainty).

1 finding from 1 review

Intervention not reported

Death from pericarditis · HIV‐positive people with tuberculous pericarditis. Most patients (80%) not on antiretroviral drugs

It is very uncertain whether the intervention changes death from pericarditis (very low certainty).

1 finding from 1 review

Acupuncture vs placebo

Perinatal mortality · Pregnant women with hyperemesis gravidarum

Acupuncture showed no clear difference in stillbirth and neonatal death compared with placebo (low certainty).

1 finding from 1 review

Corticosteroids vs placebo

Perinatal mortality · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes stillbirth and neonatal death compared with placebo (very low certainty).

1 finding from 1 review