Findings

What do systematic reviews say?

6 questions · 7 findings · 6 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 3 · 42.9%Moderate 2 · 28.6%High 0 · 0%

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 1.38 [0.21, 9.14]
2 studies · 177 participants
Very low
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.98 [1.47, 2.65]
11 studies · 1213 participants
Moderate

Metformin vs placebo or no treatment

Clinical pregnancy rate · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin probably leads to higher clinical pregnancy rate per woman compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.93 [1.42, 2.64]
9 studies · 1027 participants
Moderate

Metformin vs placebo co‐treatment

Clinical pregnancy rate · subfertile women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes only
OR 2.51 [1.46, 4.31]
5 studies · 264 participants
Low

Glucocorticoid supplementation vs placebo

Clinical pregnancy rate · Women undergoing IVF/ICSI cycles

Glucocorticoid supplementation showed no clear difference in clinical pregnancy rate per woman/couple compared with placebo (low certainty).

1 finding from 1 review

Glucocorticoid supplementation during ovarian stimulation for IVF or ICSI 2017 · Cochrane Headline outcomes only
OR 1.69 [0.98, 2.9]
2 studies · 310 participants
Low

G‐CSF vs no treatment or placebo

Clinical pregnancy rate · Subfertile women undergoing assisted reproduction

It is very uncertain whether G‐CSF changes clinical pregnancy rate per woman randomised compared with no treatment or placebo (very low certainty).

1 finding from 1 review

Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
RR 1.65 [1.32, 2.06]
12 studies · 1050 participants
Very low

Metformin vs placebo or no treatment

Clinical pregnancy rate per woman ‐ long protocol GnRH‐agonist · women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate per woman ‐ long protocol GnRH‐agonist compared with placebo or no treatment (low certainty).

1 finding from 1 review

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 1.32 [1.08, 1.63]
10 studies · 915 participants
Low