Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 4 reviews · Oral Health

No studies found 0 · 0%GRADE not reported 17 · 94.4%Very low 0 · 0%Low 1 · 5.6%Moderate 0 · 0%High 0 · 0%

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

Change in probing pocket depth (PPD) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…

Enamel matrix derivative (EMD; Emdogain) may leads to higher change in probing pocket depth (PPD) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).

1 finding from 1 review

Metronidazole gel 25% (local antibiotic) vs Ultrasonic debridement

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Metronidazole gel 25% (local antibiotic) showed no clear difference in change in probing pocket depth compared with ultrasonic debridement; GRADE not reported.

1 finding from 1 review

Erbium:YAG laser vs Air-abrasive device (Perio-Flow)

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Er:YAG laser showed no clear difference in change in probing pocket depth compared with air-abrasive device (Perio-Flow); GRADE not reported.

1 finding from 1 review

Mechanical debridement with titanium curettes vs Ultrasonic debridement

Change in probing pocket depth (PPD) · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement with titanium curettes showed no clear difference in change in probing pocket depth compared with mechanical debridement with ultrasonic device; GRADE not reported.

1 finding from 1 review

Sonic toothbrushing vs Manual toothbrushing

Change in probing pocket depth (PPD) · Adults with dental implants and peri-implant mucositis at baseline

Sonic toothbrushing showed no clear difference in change in probing pocket depth compared with manual toothbrushing; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Change in probing pocket depth (PPD) · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Phosphoric etching (acid) gel vs Mechanical debridement and polishing

Change in probing pocket depth (PPD) · Adults with dental implants and healthy peri-implant soft tissues at baseline

Phosphoric etching (acid) gel showed no clear difference in change in probing pocket depth compared with mechanical debridement and polishing; GRADE not reported.

1 finding from 1 review

Hyaluronic acid gel (brushing) vs Chlorhexidine, 0.2% to 2% (solution or gel)

Change in probing pocket depth (PPD) · Adults with dental implants and healthy peri-implant soft tissues at baseline

Hyaluronic acid gel (brushing) showed no clear difference in change in probing pocket depth compared with chlorhexidine gel (brushing); GRADE not reported.

1 finding from 1 review

Nanocrystalline hydroxyapatite (Ostim) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Nanocrystalline hydroxyapatite (Ostim) led to lower change in probing pocket depth (PPD) compared with bovine-derived xenograft (Bio-Oss) plus resorbable barrier; GRADE not reported.

1 finding from 1 review

Er:YAG laser debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Er:YAG laser debridement showed no clear difference in change in probing pocket depth (PPD) compared with manual debridement plus chlorhexidine irrigation/gel; GRADE not reported.

1 finding from 1 review

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing pocket depth (PPD) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.

1 finding from 1 review

Triclosan dentifrice vs Sodium fluoride (control) toothpaste

Change in probing pocket depth (>=4 mm) · Adults with dental implants and peri-implant mucositis at baseline

Triclosan dentifrice showed no clear difference in change in probing pocket depth (>=4 mm) compared with sodium fluoride dentifrice; GRADE not reported.

1 finding from 1 review

Mechanical debridement plus topical minocycline vs Mechanical debridement plus chlorhexidine gel

Change in probing pocket depth (worst sites) · Adults with dental implants and peri-implant mucositis at baseline

Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth (worst sites) compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.

1 finding from 1 review

Er:YAG laser surface debridement before bone augmentation vs Plastic curettes plus saline solution before bone augmentation

Change in probing pocket depth (PPD) · People with at least one dental implant affected by perimplantitis

Er:YAG laser surface debridement before bone augmentation showed no clear difference in change in probing pocket depth (PPD reduction) compared with plastic curettes plus saline solution before bone augmentation; GRADE not reported.

1 finding from 1 review

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Change in probing pocket depth (PPD) · Adults with chronic periodontitis

Occlusal adjustment as an adjunct to non-surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

1 finding from 1 review

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Change in probing pocket depth (PPD) · Adults with chronic periodontitis

Occlusal adjustment as an adjunct to surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

1 finding from 1 review