Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 11 findings · 7 reviews · Hypertension

No studies found 1 · 9.1%GRADE not reported 0 · 0%Very low 2 · 18.2%Low 3 · 27.3%Moderate 5 · 45.5%High 0 · 0%

Antihypertensive drug therapy vs control

Cardiovascular mortality and morbidity Mean duration of 3.7 years · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy may leads to lower total cardiovascular mortality + morbidity compared with control (low certainty).

1 finding from 1 review

Any antihypertensive drug vs placebo or no treatment

Cardiovascular mortality and morbidity Mean duration of 3.7 years · adults 60 years or older with primary hypertension

Antihypertensive drug probably leads to lower cardiovascular mortality and morbidity Mean duration of 3.7 years compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Aspirin vs placebo

Cardiovascular mortality · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin showed no clear difference in cardiovascular mortality compared with placebo (low certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Cardiovascular mortality · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in cardiovascular mortality compared with standard blood pressure targets (moderate certainty).

1 finding from 1 review