Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 8 reviews · Hepato-Biliary

No studies found 3 · 15.8%GRADE not reported 0 · 0%Very low 12 · 63.2%Low 4 · 21.1%Moderate 0 · 0%High 0 · 0%

Sclerotherapy vs no intervention

All‐cause mortality · primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

It is very uncertain whether sclerotherapy changes all‐cause mortality compared with no intervention (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) vs chemoembolisation

All‐cause mortality (at 1 year) · participants with unresectable hepatocellular carcinoma

It is very uncertain whether external beam radiotherapy (EBRT) changes all‐cause mortality (at 1 year) compared with transarterial chemoembolisation (TACE) (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Mortality Number of deaths at maximum · participants with unresectable hepatocellular carcinoma

External beam radiotherapy (EBRT) plus transarterial… may leads to lower all‐cause mortality (at maximum 1‐year compared with TACE alone (low certainty).

1 finding from 1 review

Gemcitabine plus oxaliplatin vs 5‐fluorouracil plus cisplatin plus radiotherapy

All‐cause mortality at 1 year · people with advanced biliary tract carcinomas

It is very uncertain whether gemcitabine plus oxaliplatin changes all‐cause mortality at 1 year compared with 5‐fluorouracil plus cisplatin plus radiotherapy (very low certainty).

1 finding from 1 review

Double‐dose adenovirus‐thymidine kinase with ganciclovir (ADV‐TK/GCV) plus liver transplantation vs liver transplantation

All‐cause mortality · participants with unresectable hepatocellular carcinoma

Double‐dose adenovirus‐thymidine kinase with ganciclovir… may leads to lower all‐cause mortality compared with liver transplantation (low certainty).

1 finding from 1 review

Adenovirus‐thymidine kinase with ganciclovir (ADV‐TK/GCV) plus liver transplantation vs liver transplantation

All‐cause mortality · participants with unresectable hepatocellular carcinoma

It is very uncertain whether adenovirus‐thymidine kinase with ganciclovir (ADV‐TK/GCV) plus liver… changes all‐cause mortality compared with liver transplantation (very low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality · people with liver metastases

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review