Findings

What do systematic reviews say?

8 questions · 8 findings · 4 reviews · Neonatal

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No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 1 · 12.5%Low 4 · 50%Moderate 0 · 0%High 0 · 0%

Enteral zinc supplementation vs no zinc supplementation

All‐cause mortality (between start of intervention and end of · preterm infants

Enteral zinc supplementation may leads to lower all‐cause mortality (between start of intervention and end of compared with no zinc supplementation (low certainty).

1 finding from 1 review

Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates 2021 · Cochrane Headline outcomes only
RR 0.55 [0.31, 0.97]
3 studies · 345 participants
Low

Intervention not reported

All‐cause mortality · newborn infants at risk of gastrointestinal bleeding

It is very uncertain whether the intervention changes all‐cause mortality (very low certainty).

1 finding from 1 review

Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants 2019 · Cochrane Headline outcomes only
RR 2.42 [0.7, 8.38]
1 study · 53 participants
Very low

Intervention not reported

All‐cause mortality · infants with upper gastrointestinal bleeding

The intervention showed no clear difference in all‐cause mortality (low certainty).

1 finding from 1 review

Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants 2019 · Cochrane Headline outcomes only
RR 0.63 [0.26, 1.51]
2 studies · 131 participants
Low

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

All‐cause mortality during hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) may leads to lower all‐cause mortality during hospital stay compared with placebo or no intervention (low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
RR 0.57 [0.35, 0.93]
6 studies · 416 participants
Low

Early paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Late paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prophylactic administration of paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm infants with PDA

Prophylactic administration of paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with placebo or no intervention (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.59 [0.24, 1.44]
3 studies · 240 participants
Low