Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

35 questions · 37 findings · 15 reviews · Gynaecology and Fertility

No studies found 12 · 32.4%GRADE not reported 0 · 0%Very low 11 · 29.7%Low 8 · 21.6%Moderate 6 · 16.2%High 0 · 0%

Metformin vs clomiphene

Gastrointestinal adverse events · women with polycystic ovary syndrome

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Metformin vs placebo or no treatment

Gastrointestinal adverse events · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin probably leads to higher adverse events (gastrointestinal) per woman compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Metformin combined with clomiphene citrate vs clomiphene

Gastrointestinal adverse events · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher adverse events (gastrointestinal) per woman compared with clomiphene citrate alone (moderate certainty).

2 findings from 2 reviews · compare the 2 reviews

Pharmacological interventions vs pharmacological intervention

Adverse events ‐ Metformin plus liraglutide vs metformin Nausea Diarrhoea Headache · obese women with subfertility

It is very uncertain whether pharmacological intervention changes adverse events ‐ Metformin plus liraglutide vs metformin Nausea… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Surgery vs LNG‐IUS

Proportion of women with adverse events Endometrial ablation versus LNG‐IUS. At one year · women with heavy menstrual bleeding

Surgery probably leads to lower proportion of women with adverse events Endometrial ablation versus… compared with LNG‐IUS (moderate certainty).

1 finding from 1 review

Oral contraceptive pill (OCP) vs metformin combined with OCP

Adverse events ‐ Severe · adolescent women with PCOS

It is very uncertain whether oral contraceptive pill (OCP) changes adverse events ‐ Severe compared with metformin combined with OCP (very low certainty).

1 finding from 1 review