Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,004 questions · 1,019 findings · 269 reviews

No studies found 333 · 32.7%GRADE not reported 106 · 10.4%Very low 313 · 30.7%Low 189 · 18.5%Moderate 66 · 6.5%High 12 · 1.2%

Locking plate vs locking intramedullary nail

Adverse events: number of participants with complications · adults undergoing surgery for displaced proximal humeral fracturesa (2 trials)

It is very uncertain whether locking plate changes adverse events: number of participants with complications compared with locking intramedullary nail (very low certainty).

1 finding from 1 review

Reverse total shoulder arthroplasty (RTSA) vs hemiarthroplasty

Adverse events: number of participants with complications · adults undergoing surgery for displaced proximal humeral fracturesa (2 trials)

It is very uncertain whether reverse total shoulder arthroplasty (RTSA) changes adverse events: number of participants with complications compared with hemiarthroplasty (very low certainty).

1 finding from 1 review

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

Proportion of participants with adverse events with a probable causal link with the study interventions at six months · adults undergoing cataract surgery with IOL implantation

The review found no eligible studies for this question.

1 finding from 1 review

Azathioprine vs methotrexate

Adverse event causing death or study drug discontinuation · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in adverse events causing death or study drug discontinuation compared with methotrexate (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events for all placebos compared with wait‐list or no treatment (Spontaneous reporting of dichotomous outcomes) (Post‐treatment) · patients with mental health disorders

It is very uncertain whether the intervention changes serious adverse events for all placebos compared with wait‐list or… (very low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious adverse events for all placebos compared with wait‐list or no treatment (Spontaneous reporting of dichotomous outcomes) (Post‐treatment) · patients with mental health disorders

It is very uncertain whether the intervention changes non‐serious adverse events for all placebos compared with wait‐list… (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events 1. All adverse events 2. Drop‐outs due to adverse events Interventions vs thiazolidinediones [1. 6 months to 12 months] [2. 24 weeks to 52 weeks] · participants with type 2 diabetes mellitus

The intervention may leads to lower adverse events 1. All adverse events 2. Drop‐outs due to adverse… (low certainty).

1 finding from 1 review