Findings

What do systematic reviews say?

10 questions · 10 findings · 7 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 1 · 10%GRADE not reported 0 · 0%Very low 5 · 50%Low 3 · 30%Moderate 1 · 10%High 0 · 0%

Imiquimod vs cidofovir

Total serious adverse events · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod showed no clear difference in total serious adverse events compared with cidofovir (moderate certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 1.26 [0.88, 1.81]
1 study · 168 participants
Moderate

Exercise vs no exercise

Adverse events · adults with breast or prostate cancer receiving radiation therapy alone

1 finding from 1 review

Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 45 participants
Very low

Modafinil vs placebo

Adverse events ( · people with a primary brain tumour

It is very uncertain whether boele 2013: modafinil changes adverse events ( compared with placebo (very low certainty).

1 finding from 1 review

Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
RR 2.79 [0.59, 13.16]
1 study · 37 participants
Very low

Bethanechol vs placebo

Adverse events

The review found no eligible studies for this question.

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Pharmacological interventions vs no intervention

Adverse events · Adults undergoing pelvic radiotherapy

1 finding from 1 review

Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with… 2018 · Cochrane Headline outcomes only
no estimate extracted
905 participants
Very low

Edaravone plus corticosteroids vs corticosteroids

Severe adverse events · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

1 finding from 1 review

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 137 participants
Low

Summary of findings: bevacizumab vs placebo

Severe adverse events · people previously treated with radiosurgery or fractionated radiotherapy to the brain or head and neck region with a diagnosis of brain…

1 finding from 1 review

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Low

Lifestyle interventions vs placebo or usual care

Adverse events – musculoskeletal · weight reduction in obesity to improve survival in women with endometrial cancer

It is very uncertain whether summary of findings table ‐ Lifestyle intervention changes adverse events – musculoskeletal compared with usual care compared to placebo (very low certainty).

1 finding from 1 review

Interventions for weight reduction in obesity to improve survival in women with endometrial cancer 2023 · Cochrane Headline outcomes only
RR 19.03 [1.17, 310.52]
8 studies · 315 participants
Very low

Suprapubic catheterisation vs intermittent self‐catheterisation

Adverse events (acute complication after surgery)

It is very uncertain whether suprapubic catheterisation changes adverse events (acute complication after surgery) compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early‐stage… 2021 · Cochrane Headline outcomes only
RR 0.77 [0.24, 2.49]
1 study · 71 participants
Very low

Porter 2020: armodafinil vs placebo

Adverse events (grade ≥ 3) · people with a primary brain tumour

1 finding from 1 review

Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 328 participants
Low