Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

150 questions · 150 findings · 48 reviews

No studies found 19 · 12.7%GRADE not reported 21 · 14%Very low 40 · 26.7%Low 39 · 26%Moderate 23 · 15.3%High 8 · 5.3%

Antihypertensive drug therapy vs control

Withdrawals due to adverse events · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

It is very uncertain whether antihypertensive drug therapy changes withdrawal due to adverse events compared with control (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events at longest · hospitalised adults with COVID‐19 (moderate to severe disease)

The intervention showed no clear difference in serious adverse events at longest (low certainty).

1 finding from 1 review

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

Serious adverse events (by day 28) · individuals with moderate or severe COVID‐19

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies… showed no clear difference in serious adverse events (by day 28) compared with saline placebo (low certainty).

1 finding from 1 review

Hydromorphone vs morphine

Vomiting · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – vomiting compared with morphine (very low certainty).

1 finding from 1 review

Hydromorphone vs fentanyl

Vomiting · people with moderate to severe cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Hydromorphone vs oxycodone

Vomiting · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – vomiting compared with oxycodone (very low certainty).

1 finding from 1 review

Hydromorphone vs morphine

Dizziness · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – dizziness compared with morphine (very low certainty).

1 finding from 1 review

Hydromorphone vs fentanyl

Dizziness · people with moderate to severe cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Hydromorphone vs oxycodone

Dizziness · people with moderate to severe cancer pain

It is very uncertain whether hydromorphone changes specific adverse events – dizziness compared with oxycodone (very low certainty).

1 finding from 1 review

Oral propranolol vs placebo

Adverse events ‐ treatment emergent · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Intervention not reported

Adverse events during study treatment · hospitalised adults with COVID‐19 (moderate to severe disease)

The review found no eligible studies for this question.

1 finding from 1 review