Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

23 questions · 23 findings · 10 reviews

No studies found 7 · 30.4%GRADE not reported 5 · 21.7%Very low 6 · 26.1%Low 1 · 4.3%Moderate 4 · 17.4%High 0 · 0%

Zinc vs placebo

Risk of adverse events, including those that may be due to zinc supplements Duration of · adults and children with colds and/or upper respiratory infections
1 finding from 1 review

Zinc vs placebo

Risk of serious adverse events, including those that may be complications of the common cold · adults and children with colds and/or upper respiratory infections

The review found no eligible studies for this question.

1 finding from 1 review

Zinc vs placebo

Adverse events · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)

It is very uncertain whether zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Chlorhexidine + zinc acetate mouthwash vs Placebo mouthwash

Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    mean 3 months
    Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
    0 studies
    No studies found

Cetylpyridinium chloride + essential oils + chlorine dioxide + zinc mouthrinse (Breath Rx) vs placebo

Adverse events · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
  • Mouthrinses for the treatment of halitosis 2008 · Cochrane All outcomes
    4 weeks
    Borden 2002: 13 adverse events were reported in the trial, but the investigators concluded that none were likely to be related to product usage.
    1 study
    GRADE not reported

0.05% chlorhexidine + 0.05% cetylpyridinium chloride + 0.14% zinc lactate mouthrinse vs Placebo mouthwash

Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…
1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    mean 2 weeks
    Adverse events (Table 6). Risk with placebo mouthwash: None reported. Risk with halita mouthwash: tongue staining was seen in patients who gargled, rather than rinsed. 40 participants (1 RCT). Certainty: VERY LOW.
    1 study · 40 participants
    Very low

0.05% chlorhexidine + 0.05% cetylpyridinium chloride + 0.14% zinc lactate mouthrinse vs placebo

Adverse events (tongue and tooth staining) · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
  • Mouthrinses for the treatment of halitosis 2008 · Cochrane All outcomes
    2 weeks
    Winkel 2003: significantly more tongue staining (P < 0.001) and tooth staining (P < 0.002) were noted with the chlorhexidine + cetylpyridinium chloride + zinc lactate mouthrinse than with placebo.
    1 study · 40 participants
    GRADE not reported

Zinc vs placebo

Adverse events number of participants hospitalised during the trial · children with cystic fibrosis

Summary of findings: Zinc supplementation showed no clear difference in adverse events number of participants hospitalised during the trial compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children aged less than 6 months with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review