Findings

What do systematic reviews say?

7 questions · 7 findings · 5 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 3 · 42.9%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%

Vitamin D vs placebo

Adverse events · people with sickle cell disease

Vitamin D showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 3.16 [0.14, 72.84]
1 study · 37 participants
Low

Vitamin D 100,000 IU/month vs 12,000 IU/month

Adverse events · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Low

Vitamin K vs control

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: oral vitamin E supplementation vs placebo or no treatment

Adverse events · adults and children with cystic fibrosis

Summary of findings: oral vitamin E supplementation showed no clear difference in adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
OR 1 [0.13, 7.94]
1 study · 38 participants
Low

Intervention not reported

Adverse events · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse events · children and adults with CF

1 finding from 1 review

Vitamin A and beta (β)‐carotene supplementation for cystic fibrosis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Angiotensin‐converting enzyme inhibitors vs vitamin C

Serious adverse events · children with sickle cell anaemia and microalbuminuria

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found