Findings

What do systematic reviews say?

107 questions · 108 findings · 22 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 26 · 24.1%GRADE not reported 0 · 0%Very low 23 · 21.3%Low 30 · 27.8%Moderate 26 · 24.1%High 3 · 2.8%

Summary of findings: ECM vs ECT

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs ECMM

Adverse events · children with cystic fibrosis and proven pancreatic insufficiency

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs TPE

Adverse events · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs other enteric‐coated preparations

Adverse events · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ECM vs NECT plus cimetidine

Adverse events · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ACBT vs PEP mask therapy

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Active cycle of breathing technique for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ACBT vs OD

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Active cycle of breathing technique for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ACBT vs other breathing techniques

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Active cycle of breathing technique for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ACBT vs CCPT

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Active cycle of breathing technique for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: ACBT vs exercise

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Active cycle of breathing technique for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Summary of findings ‐ PEP vs oscillating PEP

Adverse events · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
22 participants
Low

Summary of findings ‐ PEP vs HFCWO

Adverse events · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 107 participants
High

Summary of findings ‐ PEP vs BiPAP

Adverse events · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
20 participants
Low

Summary of findings ‐ PEP vs airway clearance techniques

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ PEP vs PDPV

Adverse events · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 66 participants
Low

Summary of findings: low‐dose vs high‐dose PERT

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 146 participants
Very low

Exercise vs no intervention

Adverse events · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: β‐carotene vs placebo

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Summary of findings ‐ ivacaftor vs placebo

Adverse events · adults and children with cystic fibrosis and with at least one G551D CFTR mutation

1 finding from 1 review

Potentiators (specific therapies for class III and IV mutations) for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 232 participants
Low

Summary of findings ‐ ivacaftor vs placebo

Adverse events · adults and children with cystic fibrosis and with at least one R117H CFTR mutation

1 finding from 1 review

Potentiators (specific therapies for class III and IV mutations) for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 69 participants
Low