What do systematic reviews say?

Photodynamic therapy plus mechanical debridement vs Mechanical debridement alone

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

Low‐level laser therapy vs Placebo (sham) laser therapy

The review found no eligible studies for this question.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
  SoF row 'Adverse events': This outcome was not reported in the included studies.
  0 studies
  No studies found

In-office laser therapy (all types combined) vs Placebo (placebo laser or placebo agent) or no treatment

• Laser therapy for dentinal hypersensitivity 2021 · Cochrane All outcomes

  Air blast stimuli studies (SoF 1)
  No adverse event was noted in the experimental and control groups
  11 studies · 954 participants
  Low
• Laser therapy for dentinal hypersensitivity 2021 · Cochrane All outcomes

  Tactile stimuli studies (SoF 2)
  No adverse event was noted in the experimental and control groups
  5 studies · 386 participants
  Low

Surgery plus radiotherapy vs Radiotherapy alone

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Adverse events: severe acute effects in both groups (subcutaneous fibrosis, telangiectasia, moderate-to-severe oedema, xerostomia, trismus, dysphagia); subcutaneous fibrosis more prevalent with surgery + radiotherapy…
  1 study · 35 participants
  Very low

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

• Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes

  High-dose melphalan-based treatment prior to HSCT (haematological cancers)
  Adverse events reported narratively: one study did not report adverse events (Askarifar 2015); another reported no serious adverse events (Toro 2013); the remaining two reported low rates of shooting pain from the…
  3 studies
  GRADE not reported
• Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy 2015 · Cochrane All outcomes

  Fluorouracil (5FU) treatment for solid cancers
  Adverse events reported narratively (not meta-analysed): one study reported no adverse effects (Katranci 2012); the other four 5FU studies reported low rates of very minor adverse events (headache, chills,…
  5 studies · 444 participants
  GRADE not reported

Surgery plus radiotherapy vs Chemotherapy (chemoradiotherapy)

The review found no eligible studies for this question.

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Adverse events: not reported for any participants (Iyer 2015).
  0 studies
  No studies found

CBT vs inactive control (usual care care, attention control, waitlist)

• Psychological therapies for temporomandibular disorders (TMDs) 2022 · Cochrane All outcomes
  Only 1 study reported adverse events as an outcome (Litt 2010): it found worsening symptoms in 13 people treated with an oral splint (as part of standard treatment) and 4 people treated with CBT.
  1 study · 101 participants
  Very low

CBT vs alternative treatment

• Psychological therapies for temporomandibular disorders (TMDs) 2022 · Cochrane All outcomes
  SoF: 3 studies reported minor adverse events in the control group; 1 study reported minor adverse events in psychological therapy group; 1 study reported that there were no adverse events. Results: NCT00066937 minor…
  5 studies
  Very low

PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy

• Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment 2023 · Cochrane All outcomes
  Adverse events: 22 surgical complications in the PET-CT group vs 83 in the planned-surgery group (Mehanna 2017).
  1 study · 564 participants
  Very low

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic… showed no clear difference in side effects or other adverse events compared with placebo, no intervention or usual care (with or without placebo) (low certainty).

• Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease… 2019 · Cochrane All outcomes

  Up to 10 days postoperative
  RD 0.034 [-0.32, 0.38]
  2 studies · 59 participants
  Low

Amoxicillin + metronidazole + SRP vs Supragingival scaling (plus placebo)

It is very uncertain whether scaling and root planing (SRP) plus antibiotics (amoxicillin and… changes adverse events due to periodontal therapy compared with supragingival scaling (plus placebo) (very low certainty).

• Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes

  12 months
  Peto OR 0.14 [0.00, 6.90]
  1 study · 165 participants
  Very low

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

• Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes

  6 to 25 months
  Adverse events: because of variable follow-up (6 to 25 months) and almost 90% loss to follow-up by one year, results were not considered useful for analysis; uncertain whether adverse events are more likely with either…
  1 study · 303 participants
  GRADE not reported

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in side effects or other adverse events requiring withdrawal compared with placebo (placebo solution/mouthwash) (moderate certainty).

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes

  7 days
  RD 0.00 [-0.04, 0.04]
  2 studies · 128 participants
  Moderate

Glass ionomer cement vs Amalgam restoration

The review found no eligible studies for this question.

• Materials for retrograde filling in root canal therapy 2021 · Cochrane All outcomes
  Adverse events: outcome was not assessed by the included studies
  0 studies
  No studies found

Mineral trioxide aggregate (MTA) vs Intermediate restorative material (IRM)

The review found no eligible studies for this question.

• Materials for retrograde filling in root canal therapy 2021 · Cochrane All outcomes
  Adverse events: outcome was not assessed by the included studies
  0 studies
  No studies found

Mineral trioxide aggregate (MTA) vs Super ethoxybenzoic acid (Super-EBA)

The review found no eligible studies for this question.

• Materials for retrograde filling in root canal therapy 2021 · Cochrane All outcomes
  Adverse events: outcome was not assessed by the included studies
  0 studies
  No studies found

Mineral trioxide aggregate (MTA) vs Root repair material (RRM)

The review found no eligible studies for this question.

• Materials for retrograde filling in root canal therapy 2021 · Cochrane All outcomes
  Adverse events: outcome was not assessed by the included studies
  0 studies
  No studies found

Dentine-bonded resin composite vs Glass ionomer cement (GIC)

The review found no eligible studies for this question.

• Materials for retrograde filling in root canal therapy 2021 · Cochrane All outcomes
  Adverse events: outcome was not assessed by the included studies
  0 studies
  No studies found

Super ethoxybenzoic acid (Super-EBA) vs Intermediate restorative material (IRM)

The review found no eligible studies for this question.

• Materials for retrograde filling in root canal therapy 2021 · Cochrane All outcomes
  Adverse events: outcome was not assessed by the included studies
  0 studies
  No studies found

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  See comment. Killeen 2016 reported no adverse events at follow-up examinations in either study arm. Tonetti 2012 reported that there were no serious adverse events.
  2 studies · 251 participants
  GRADE not reported