Adverse events · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction
Low dose naldemedine showed no clear difference in adverse events compared with higher doses (low certainty).
1 finding from 1 review
Adverse events · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
Methylnaltrexone lower dose showed no clear difference in adverse events compared with higher dose (low certainty).
1 finding from 1 review
Serious adverse eventsg · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction
Low dose naldemedine showed no clear difference in serious adverse eventsg compared with higher doses (low certainty).
1 finding from 1 review
Serious adverse events · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events · chronic pain (excluding headache) in adults
1 finding from 1 review
Adverse events · cancer cachexia in adults
1 finding from 1 review
Adverse events NRS (scale from 0 to 10; lower score = less toxicity) · adults aged 18 years and older receiving palliative care
1 finding from 1 review
AEs · chronic pain (excluding headache) in adults
Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review
Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review
Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review
Intervention not reported
Serious adverse events · adults with complex regional pain syndrome type 1 (lower limb)
1 finding from 1 review
no estimate extracted
20 participants
Very low
Intervention not reported
Withdrawals ‐ adverse events Acute and chronic conditions combined · adults with strains or sprains (acute) or osteoarthritis or low back pain (chronic)
1 finding from 1 review
Intervention not reported
Adverse events ‐ any adverse events Acute and chronic conditions combined · adults with strains or sprains (acute) or osteoarthritis or low back pain (chronic)
1 finding from 1 review
Intervention not reported
Adverse events ‐ local adverse events Acute and chronic conditions combined · adults with strains or sprains (acute) or osteoarthritis or low back pain (chronic)
1 finding from 1 review