Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Pain, Palliative and Supportive Care

No studies found 0 · 0%GRADE not reported 1 · 33.3%Very low 0 · 0%Low 1 · 33.3%Moderate 0 · 0%High 1 · 33.3%

CNS adverse events · adults undergoing surgery

1 finding from 1 review

Perioperative intravenous ketamine for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
105 studies · 6538 participants
High

Adverse events · adults receiving intravenous opioids

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
RR 2.34 [0.47, 11.61]
3 studies · 527 participants
Low

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
2 out of 3 studies reported this outcome. Both studies reported no difference between groups (Rajamani 2007 and Simion 2008: no adverse events attributable to either technique; Delgado 2005 did not report).
2 studies
GRADE not reported