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Evidence found and GRADE certainty

22 questions · 22 findings · 8 reviews · Musculoskeletal

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No studies found 8 · 36.4%GRADE not reported 1 · 4.5%Very low 1 · 4.5%Low 8 · 36.4%Moderate 4 · 18.2%High 0 · 0%

Biofeedback vs usual care

Adverse events post‐intervention ‐ not reported · patients with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Mindfulness vs usual care

Adverse events post‐intervention ‐ not reported · patients with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Relaxation vs usual care

Adverse events post‐intervention ‐ not reported · patients with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Movement therapies vs usual care

Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · patients with fibromyalgia

It is very uncertain whether movement therapies changes adverse events post‐intervention Number of people reporting an… compared with usual care (very low certainty).

1 finding from 1 review

Psychological therapies vs usual care

Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · patients with fibromyalgia

Psychological therapies showed no clear difference in adverse events post‐intervention Number of people reporting an… compared with usual care (low certainty).

1 finding from 1 review

Monthly pegloticase vs placebo

Total adverse events · participants with tophi in gout

Monthly pegloticase showed no clear difference in total adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Exercise vs no intervention

Withdrawals due to adverse events · adults with ankylosing spondylitis

Exercise programmes showed no clear difference in withdrawals because of adverse events Exercise programme duration:… compared with no intervention (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events ‐ not measured · patients with acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Monthly pegloticase vs placebo

Withdrawals due to adverse events · participants with tophi in gout

Monthly pegloticase probably leads to higher number of participant withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Lesinurad 400 mg plus febuxostat CONTINUED vs lesinurad 200 mg plus febuxostat CONTINUED

Withdrawals due to adverse events · participants with tophi in gout

Lesinurad 400 mg plus febuxostat CONTINUED showed no clear difference in number of participant withdrawals due to adverse events compared with lesinurad 200 mg plus febuxostat CONTINUED (low certainty).

1 finding from 1 review

Pegloticase every two weeks (biweekly) vs placebo

Withdrawals due to adverse events · participants with tophi in gout

Pegloticase every two weeks (biweekly) probably leads to higher number of participant withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review