Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

415 questions · 415 findings · 128 reviews · Headline outcomes only

No studies found 92 · 22.2%GRADE not reported 8 · 1.9%Very low 130 · 31.3%Low 113 · 27.2%Moderate 57 · 13.7%High 15 · 3.6%

Quinolone vs macrolides

Quality of life Drug resistance/microbial sensitivity Serious adverse events Lung function Hospitalisations Adverse events/side effects Number of participants colonised with P aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Quinolone vs tetracycline

Quality of life Drug resistance/microbial sensitivity Serious adverse events Lung function Hospitalisations Adverse events/side effects Number of participants colonised with P aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Oral 5‐aminosalicylic acid vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Withdrawals due to adverse events · Patients with quiescent ulcerative colitis

It is very uncertain whether oral 5‐aminosalicylic acid changes withdrawal due to adverse events compared with comparator 5‐aminosalicylic acid formulation (very low certainty).

1 finding from 1 review

Glycopeptide (vancomycin or teicoplanin) plus aminoglycoside (gentamicin) vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Adverse events · people with endocarditis due to Staphylococcus aureus in drug abusers

It is very uncertain whether glycopeptide (vancomycin or teicoplanin) plus aminoglycoside… changes adverse events compared with beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin) (very low certainty).

1 finding from 1 review

Allopurinol vs placebo

Serious adverse events · people with chronic gout

Allopurinol showed no clear difference in serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review