Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

26 questions · 27 findings · 14 reviews

No studies found 5 · 18.5%GRADE not reported 0 · 0%Very low 12 · 44.4%Low 6 · 22.2%Moderate 3 · 11.1%High 1 · 3.7%

Marine‐derived n‐3 fatty acids therapy vs No marine‐derived n‐3 fatty acids therapy

Adverse events · stroke and/or TIA

Marine‐derived n‐3 fatty acids therapy showed no clear difference in adverse events compared with no marine‐derived n‐3 fatty acids therapy (low certainty).

2 findings from 1 review

Omega‐3 vs placebo

Diarrhoea · adults and children with cystic fibrosis

It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes adverse events: diarrhoea compared with placebo (very low certainty).

1 finding from 1 review

Higher polyunsaturated fatty acid (PUFA) vs lower PUFA

Major adverse cardiac and cerebrovascular events · people with or without existing CVD, men and women

It is very uncertain whether higher polyunsaturated fatty acid (PUFA) changes major adverse cardiac and cerebrovascular events compared with lower PUFA (very low certainty).

1 finding from 1 review

Omega‐3 vs placebo

Adverse effects: neurological, extrapyramidal UKU (events) Medium‐term · people in the prodromal stage of psychosis

Group A: omega‐3 fatty acids showed no clear difference in adverse effects: neurological, extrapyramidal UKU (events) Medium‐term compared with placebo (low certainty).

1 finding from 1 review

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Adverse effects (cardiac) · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

It is very uncertain whether omega‐3 fatty acids and antioxidants changes cardiac adverse events (study author reported anytime during study… compared with placebo or standard nutrition (very low certainty).

1 finding from 1 review

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Study author‐reported adverse events · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

It is very uncertain whether omega‐3 fatty acids and antioxidants changes total number of adverse events (study author reported anytime during… compared with placebo or standard nutrition (very low certainty).

1 finding from 1 review

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Gastrointestinal adverse events · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

It is very uncertain whether omega‐3 fatty acids and antioxidants changes gastrointestinal adverse events (study author reported anytime… compared with placebo or standard nutrition (very low certainty).

1 finding from 1 review