Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 13 findings · 3 reviews · Skin

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 46.2%Low 5 · 38.5%Moderate 2 · 15.4%High 0 · 0%

Mild clobetasol propionate cream regimen (10 to 30 g/day) vs standard clobetasol propionate cream regimen (40 g/day)

Adverse events at 1 year · bullous pemphigoid

Mild clobetasol propionate cream regimen (10 to 30 g/day) showed no clear difference in adverse events at 1 year compared with standard clobetasol propionate cream regimen (40 g/day) (low certainty).

1 finding from 1 review

Clobetasol propionate cream vs prednisone

Adverse events: severe complications at day 21 · bullous pemphigoid

Clobetasol propionate cream may leads to lower adverse events: severe complications at day 21 compared with oral prednisone (low certainty).

1 finding from 1 review

Very potent vs potent topical corticosteroid

Local adverse events: skin thinning; end of treatment (1 to 3 weeks) · adults with eczema

It is very uncertain whether very potent changes local adverse events: skin thinning; end of treatment (day 11‐day 22) compared with potent topical corticosteroid (very low certainty).

1 finding from 1 review

Moderate‐potency vs mild‐potency topical corticosteroid

Systemic adverse events: abnormal cortisol; end of treatment (1‐6 weeks) · children and adults with mild to severe eczema

It is very uncertain whether moderate‐potency changes systemic adverse events: abnormal cortisol; end of treatment (6‐28… compared with mild‐potency topical corticosteroid (very low certainty).

1 finding from 1 review