Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Musculoskeletal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 3 · 75%Moderate 0 · 0%High 0 · 0%

Bisphosphonates vs control

Serious adverse events · adults with GIOP

Bisphosphonates showed no clear difference in serious adverse events compared with control (low certainty).

1 finding from 1 review

Bisphosphonates for steroid‐induced osteoporosis 2016 · Cochrane Headline outcomes only
RR 0.91 [0.74, 1.12]
15 studies · 1703 participants
Low

Bisphosphonates vs control

Withdrawals due to adverse events · adults with GIOP

Bisphosphonates showed no clear difference in withdrawals due to adverse events compared with control (low certainty).

1 finding from 1 review

Bisphosphonates for steroid‐induced osteoporosis 2016 · Cochrane Headline outcomes only
RR 1.06 [0.77, 1.47]
15 studies · 1790 participants
Low

Bisphosphonates vs placebo

Withdrawals due to adverse events · Paget's disease of bone

Bisphosphonates showed no clear difference in number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
RR 1.01 [0.41, 2.52]
6 studies · 517 participants
Low

Zoledronate vs pamidronate or risedronate

Withdrawals due to adverse events · Paget's disease of bone

It is very uncertain whether zoledronate changes number of participants who withdrew due to adverse events… compared with pamidronate or risedronate (very low certainty).

1 finding from 1 review

Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
RR 2.04 [0.43, 9.59]
2 studies · 437 participants
Very low