Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

211 questions · 212 findings · 75 reviews

No studies found 44 · 20.8%GRADE not reported 17 · 8%Very low 70 · 33%Low 49 · 23.1%Moderate 28 · 13.2%High 4 · 1.9%

Topical prophylaxis vs no topical prophylaxis

Gastrointestinal adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical prophylaxis showed no clear difference in gastrointestinal adverse events compared with no topical prophylaxis (low certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Gastrointestinal adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in gastrointestinal adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events: superficial infection · adults with open long bone fractures; study in the review included only Gustilo II open tibia fractures

It is very uncertain whether the intervention changes adverse events: superficial infection (very low certainty).

1 finding from 1 review

Timing of wound closure (immediate vs delayed)

Adverse events ‐ superficial infection · adults with open long bone fractures of the upper and lower limbs

It is very uncertain whether timing of wound closure (immediate changes adverse events ‐ superficial infection compared with delayed) (very low certainty).

1 finding from 1 review

Fluoroquinolones vs beta‐lactams

Other adverse events clinical criteria · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes other adverse events clinical criteria compared with beta‐lactams (very low certainty).

1 finding from 1 review

Fluoroquinolones vs macrolides

Other adverse events clinical criteria · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes other adverse events clinical criteria compared with macrolides (very low certainty).

1 finding from 1 review