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Evidence found and GRADE certainty

1,514 questions · 1,543 findings · 649 reviews

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No studies found 224 · 14.5%GRADE not reported 105 · 6.8%Very low 383 · 24.8%Low 447 · 29%Moderate 293 · 19%High 91 · 5.9%

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Study author‐reported adverse events · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

It is very uncertain whether omega‐3 fatty acids and antioxidants changes total number of adverse events (study author reported anytime during… compared with placebo or standard nutrition (very low certainty).

1 finding from 1 review

Vitamin D vs placebo

Proportion of participants with one or more serious adverse events due to any cause · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more serious adverse events… compared with placebo (high certainty).

1 finding from 1 review

Alpha‐blockers vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 1: Alpha‐blockers showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Antipsychotics vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 2: Antipsychotics showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

1 finding from 1 review

MAOIs vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 3: MAOIs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

Acyclovir showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Clarithromycin vs placebo

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Gastrointestinal adverse events · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

It is very uncertain whether omega‐3 fatty acids and antioxidants changes gastrointestinal adverse events (study author reported anytime… compared with placebo or standard nutrition (very low certainty).

1 finding from 1 review

Oral propranolol vs placebo

Adverse events experienced at short or long term ‐ Serious adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in adverse events experienced at short or long term ‐ Serious adverse… compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Proportion of participants who withdrew due to adverse events between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher proportion of participants who withdrew due to adverse events… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Adverse events as N of participants with at least one adverse event objective · patients with the treatment of cocaine dependence

It is very uncertain whether summary of findings table – disulfiram changes any adverse events (number of participants who experienced at least… compared with placebo or no pharmacological treatment (very low certainty).

1 finding from 1 review

Chemical peeling vs placebo or no treatment

Serious or severe adverse events N of participants with positive severe adverse events · people with acne scars

It is very uncertain whether chemical peeling changes serious or severe adverse events N of participants with positive… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Zinc vs placebo

Risk of adverse events, including those that may be due to zinc supplements Duration of · adults and children with colds and/or upper respiratory infections
1 finding from 1 review