Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

230 questions · 231 findings · 98 reviews

No studies found 73 · 31.6%GRADE not reported 10 · 4.3%Very low 71 · 30.7%Low 50 · 21.6%Moderate 20 · 8.7%High 7 · 3%

Intervention not reported

Serious adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review

Chemmotherapy combined with biological therapy vs chemotherapy alone

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

It is very uncertain whether chemmotherapy combined with biological therapy changes serious adverse events compared with chemotherapy (very low certainty).

1 finding from 1 review

Chemotherapy vs placebo, best supportive care (BSC) or no treatment

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Chemotherapy probably leads to higher serious adverse events compared with placebo, best supportive care (BSC) or no treatment (moderate certainty).

1 finding from 1 review

Biological therapy vs placebo, best supportive care (BSC) or no treatment

Serious adverse events · advanced gastric and oesophago‐gastric junction adenocarcinoma

Biological therapy showed no clear difference in serious adverse events compared with placebo, best supportive care (BSC) or no treatment (low certainty).

1 finding from 1 review

Cyclophosphamide vs methylprednisolone

Adverse events ‐ Death · patients with neuropsychiatric involvement in systemic lupus erythematosus

It is very uncertain whether cyclophosphamide changes adverse events ‐ Death compared with methylprednisolone (very low certainty).

1 finding from 1 review

Carvedilol vs beta‐blocker

Non‐serious adverse events · adults with cirrhosis and gastroesophageal varices

It is very uncertain whether carvedilol changes non‐serious adverse events compared with traditional, non‐selective beta‐blockers (very low certainty).

1 finding from 1 review

Antihypertensive drug therapy vs placebo or no treatment

Total serious adverse events · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes total serious adverse events compared with placebo or no treatment (very low certainty).

1 finding from 1 review