Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,004 questions · 1,019 findings · 269 reviews

No studies found 333 · 32.7%GRADE not reported 106 · 10.4%Very low 313 · 30.7%Low 189 · 18.5%Moderate 66 · 6.5%High 12 · 1.2%

Primary health professional‐led psychological interventions vs usual care or no treatment

Adverse events (RR > 1 denotes greater risk of harm) · adults with post‐traumatic stress or common mental disorders

It is very uncertain whether primary health professional‐led psychological interventions changes adverse events (RR > 1 denotes greater risk of harm) compared with usual or no care (very low certainty).

1 finding from 1 review

Psychosocial interventions vs inactive control

Adverse events (a count of reported harms or adverse events/experiences over life of study/ · survivors of sexual violence and abuse

It is very uncertain whether summary of findings table ‐ Psychosocial interventions changes adverse events (a count of reported harms or adverse… compared with inactive control (very low certainty).

1 finding from 1 review

Multi‐component interventions (with telehealth as a component of care) vs usual care

Adverse events: number of people with 1 or more (all‐cause) · patients with chronic obstructive pulmonary disease

It is very uncertain whether multi‐component interventions (with telehealth as a component of care) changes adverse events: number of people with 1 or more (all‐cause) compared with usual care (very low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in infants with Severe Adverse Events compared with a once‐daily NVP regimen administered (high certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 28 weeks showed no clear difference in infants with Severe Adverse Events compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

Infants with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infants with Severe Adverse Events compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis

Mothers with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… may leads to higher mothers with Severe Adverse Events compared with 1 week of antiretroviral prophylaxis (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Infants with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infants with Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review

An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants

Mothers with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

An extended antiretroviral regimen administered to mothers for 28… may leads to higher mothers with Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Adverse events (1 to 6 months post intervention) ‐ incidence of alcohol‐related consequences ‐ accidents (RR > 1 denotes greater risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes adverse events (1 to 6 months post intervention) ‐ incidence of… compared with enhanced usual care (very low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP plus ZDV regimen administered to infants for 14 weeks changes infants with any Severe Adverse Events compared with sdNVP plus ZDV (1 week) (very low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… may leads to higher infants with any Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review