Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

151 questions · 152 findings · 61 reviews

No studies found 20 · 13.2%GRADE not reported 4 · 2.6%Very low 53 · 34.9%Low 39 · 25.7%Moderate 24 · 15.8%High 12 · 7.9%

Intervention not reported

Serious adverse events · people with pressure ulcers

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review

Summary of findings: intravitreal bevacizumab plus intravitreal steroid vs intravitreal anti‐VEGF

Systemic adverse events at · adults with centre‐involving diabetic macular oedema

Summary of findings: intravitreal anti‐VEGF plus intravitreal steroid showed no clear difference in systemic adverse events at compared with intravitreal anti‐VEGF (low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious adverse events · people with pressure ulcers

The intervention may leads to higher non‐serious adverse events (low certainty).

1 finding from 1 review

Anti‐IL‐5 mAb (mepolizumab) vs placebo (on top of topical steroids)

Adverse events ‐ nasopharyngitis, including sore throat · patients with severe chronic rhinosinusitis with nasal polyps

Anti‐IL‐5 mAb (mepolizumab) showed no clear difference in adverse events ‐ nasopharyngitis, including sore throat compared with placebo (on top of topical steroids) (low certainty).

1 finding from 1 review

Anti‐IgE mAb (omalizumab) vs placebo (on top of topical steroids)

Adverse events ‐ nasopharyngitis, including sore throat · patients with chronic rhinosinusitis with nasal polyps

Anti‐IgE mAb (omalizumab) showed no clear difference in adverse events ‐ nasopharyngitis, including sore throat compared with placebo (on top of topical steroids) (low certainty).

1 finding from 1 review