Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,199 questions · 1,226 findings · 451 reviews

No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

Casirivimab/imdevimab vs placebo

Adverse events: grade 1 to 2 · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

The review found no eligible studies for this question.

2 findings from 1 review

Calcineurin inhibitors ± steroids vs alkylating agents ± steroids

Adverse events ‐ infection ( · primary membranous nephropathy in adults with nephrotic syndrome

Calcineurin inhibitors ± steroids showed no clear difference in adverse events ‐ infection ( compared with alkylating agents ± steroids (low certainty).

1 finding from 1 review

Larger atraumatic needles vs atraumatic needles

Paraesthesia · patients undergoing lumbar punctures with atraumatic needles (Whitacre, Atraucan, Sprotte, Cappe‐Deutsh, Pajunk, Gertie Marx, Durasafe,…

Larger atraumatic needles probably leads to lower adverse events: paraesthesia compared with smaller atraumatic needles (moderate certainty).

1 finding from 1 review

Band ligation vs no intervention or a sham procedure

Serious adverse events Idiopathic thrombocytopaenic purpura · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment

It is very uncertain whether band ligation changes serious adverse events Idiopathic thrombocytopaenic purpura compared with sham or no intervention (very low certainty).

1 finding from 1 review

Hysterectomy with opportunistic salpingectomy vs hysterectomy without opportunistic salpingectomy

Surgery‐related adverse events: intraoperative complications · premenopausal women undergoing hysterectomy for benign gynaecological indications

It is very uncertain whether hysterectomy with opportunistic salpingectomy changes surgery‐related adverse events: intraoperative complications compared with hysterectomy without opportunistic salpingectomy (very low certainty).

1 finding from 1 review

Calcium vs placebo

Adverse events: renal calculi · white healthy postmenopausal women over 55 years

Calcium showed no clear difference in adverse events: renal calculi compared with placebo (low certainty).

1 finding from 1 review

Summary of findings: high‐dose urate oxidase vs low‐dose urate oxidase

Frequency of adverse events ( · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: high‐dose urate oxidase showed no clear difference in frequency of adverse events ( compared with low‐dose urate oxidase (low certainty).

1 finding from 1 review