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Evidence found and GRADE certainty

891 questions · 902 findings · 317 reviews

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No studies found 210 · 23.3%GRADE not reported 56 · 6.2%Very low 236 · 26.2%Low 220 · 24.4%Moderate 146 · 16.2%High 34 · 3.8%

Alpha‐blockers vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 1: Alpha‐blockers showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Antipsychotics vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 2: Antipsychotics showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

1 finding from 1 review

MAOIs vs placebo

Dropouts due to adverse events · adults (aged 18‐85)

Comparison 3: MAOIs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs antipsychotics

Risk for at least one adverse event per patient · schizophrenia

It is very uncertain whether summary of findings table ‐ CBT without antipsychotics changes adverse events ‐ Participants with at least one AE (separated time… compared with antipsychotics (very low certainty).

1 finding from 1 review

Summary of findings table ‐ CBT without antipsychotics vs CBT plus antipsychotics

Risk for at least one adverse event per patient · schizophrenia

Summary of findings table ‐ CBT without antipsychotics may leads to lower adverse events ‐ Participants with at least one AE (separated time… compared with CBT plus antipsychotics (low certainty).

1 finding from 1 review

Surgery vs LNG‐IUS

Proportion of women with adverse events Endometrial ablation versus LNG‐IUS. At one year · women with heavy menstrual bleeding

Surgery probably leads to lower proportion of women with adverse events Endometrial ablation versus… compared with LNG‐IUS (moderate certainty).

1 finding from 1 review

Brivaracetam vs placebo

Withdrawals due to adverse events · people with drug‐resistant focal epilepsy

Brivaracetam may leads to higher proportion of participants who experienced adverse events leading to… compared with placebo (low certainty).

1 finding from 1 review

Cipaglucosidase plus miglustat vs alglucosidase alfa plus placebo

Treatment‐related AEs: total treatment‐emergent adverse events potentially related to treatment · adults with LOPD

Cipaglucosidase plus miglustat showed no clear difference in treatment‐related AEs: total treatment‐emergent adverse events… compared with alglucosidase alfa plus placebo (low certainty).

1 finding from 1 review

Avalglucosidase alfa vs alglucosidase alfa

Treatment‐related AEs: total treatment‐emergent adverse events potentially related to treatment · adults with LOPD

Avalglucosidase alfa showed no clear difference in treatment‐related AEs: total treatment‐emergent adverse events… compared with alglucosidase alfa (low certainty).

1 finding from 1 review

Autologous blood or PRP vs placebo at 3 months' follow‐up

Adverse events (pain and swelling at injection site and limitation of elbow movement following injection) · lateral elbow pain

Autologous blood or PRP showed no clear difference in adverse events (pain and swelling at injection site and limitation… compared with placebo at 3 months' follow‐up (low certainty).

1 finding from 1 review

Movement therapies vs usual care

Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · patients with fibromyalgia

It is very uncertain whether movement therapies changes adverse events post‐intervention Number of people reporting an… compared with usual care (very low certainty).

1 finding from 1 review

Psychological therapies vs usual care

Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · patients with fibromyalgia

Psychological therapies showed no clear difference in adverse events post‐intervention Number of people reporting an… compared with usual care (low certainty).

1 finding from 1 review

Multi‐component intervention vs control

Adverse events: number of people experiencing adverse events (all cause or COPD‐related), serious adverse events, mortality · COPD

Multi‐component intervention showed no clear difference in adverse events: number of people experiencing adverse events (all… compared with control (low certainty).

1 finding from 1 review

Single component intervention vs control

Adverse events: number of people experiencing adverse events (all cause or COPD‐related), serious adverse events, mortality · COPD

It is very uncertain whether single component intervention changes adverse events: number of people experiencing adverse events (all… compared with control (very low certainty).

1 finding from 1 review

Abiraterone + ADT vs ADT only

Adverse events grade 3 to 5 Range of · men with metastatic, hormone‐sensitive prostate cancer

Abiraterone + ADT leads to higher grades III to V adverse events (severe and life threatening, as per… compared with ADT alone (high certainty).

1 finding from 1 review

Fexofenadine 120 mg/d vs placebo (1‐week intervention)

Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · adults with eczema

Fexofenadine 120 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (1‐week intervention) (moderate certainty).

1 finding from 1 review

Loratadine 10 mg vs placebo (4‐week intervention)

Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · adults with eczema

Loratadine 10 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (4‐week intervention) (low certainty).

1 finding from 1 review