Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

891 questions · 902 findings · 317 reviews

No studies found 210 · 23.3%GRADE not reported 56 · 6.2%Very low 236 · 26.2%Low 220 · 24.4%Moderate 146 · 16.2%High 34 · 3.8%

Comparison 13: SSRIs vs placebo

Dropouts due to adverse events · adults with SAnD

It is very uncertain whether comparison 13: SSRIs changes dropouts due to adverse events (long term) Post‐treatment: 1‐4 months compared with placebo (very low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Women With Any Severe Adverse Events Requiring Treatment Modification · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

It is very uncertain whether mma Bana: AZT/3TC/LPV‐r changes women With Any Severe Adverse Events Requiring Treatment Modification compared with AZT/3TC/ABC (very low certainty).

1 finding from 1 review

Glutamate modulators vs placebo

Dropouts due to adverse events · children and adolescents with trichotillomania

Glutamate modulators showed no clear difference in tolerability of treatment ‐ dropouts due to adverse eventscDropout… compared with placebo (low certainty).

1 finding from 1 review

TCAs with predominantly SRI actions vs placebo

Dropouts due to adverse events · adults with trichotillomania

It is very uncertain whether TCAs with predominantly SRI actions changes tolerability of treatment ‐ dropouts due to adverse eventsdDropout… compared with placebo (very low certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to treatment failure due to adverse events All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine leads to lower time to treatment failure due to adverse events All participants… compared with phenytoin (primary outcomes) (high certainty).

1 finding from 1 review

Bae: AZT/3TC/NVP vs Other Short Course Regimen

Maternal Grade 3/4 Severe Adverse Events Requiring Treatment Modification · HIV‐infected pregnant women

It is very uncertain whether tonwe‐Gold: AZT/3TC/NVP changes maternal Grade 3/4 Severe Adverse Events Requiring Treatment… compared with other Short Course Regimen (very low certainty).

1 finding from 1 review

Adjunctive Coriolus versicolor vs no adjunctive treatment

Adverse events: Oral cavity disorders (includes oral dryness and mucositis)‐ · adults (aged 18+) with colorectal cancer

It is very uncertain whether adjunctive Coriolus versicolor changes adverse events: Oral cavity disorders (includes oral dryness and… compared with no adjunctive treatment (very low certainty).

1 finding from 1 review

Intervention not reported

MST vs ECT ‐ adverse events that led to discontinuation of treatment (short term) · patients with schizophrenia
1 finding from 1 review