Findings

What do systematic reviews say?

1,199 questions · 1,226 findings · 451 reviews

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No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

Herbal preparations vs placebo

Adverse events · women with uterine fibroids

The review found no eligible studies for this question.

1 finding from 1 review

Herbal preparations for uterine fibroids 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Herbal preparations vs medication

Adverse events · women with uterine fibroids

1 finding from 1 review

Herbal preparations for uterine fibroids 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Adverse events · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

1 finding from 1 review

Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
To 6 months
Baysan 2003 stated that no adverse events were reported to 6 months; no information was provided by Abu-Naba'a 2003 or Abu-Naba'a 2003pilot.
1 study
GRADE not reported

Prebiotic vs probiotic

Total adverse events · people in remission or with mildly activeulcerative colitis

The review found no eligible studies for this question.

1 finding from 1 review

Prebiotics for induction and maintenance of remission in ulcerative colitis 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prebiotic vs synbiotics

Total adverse events · people in remission or with mildly activeulcerative colitis

The review found no eligible studies for this question.

1 finding from 1 review

Prebiotics for induction and maintenance of remission in ulcerative colitis 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prebiotic vs placebo

Total adverse events · people with mild‐to‐moderate disease (Rachmilewitz index) or active disease (SCCAI score of 4 to 10)

The review found no eligible studies for this question.

1 finding from 1 review

Prebiotics for induction and maintenance of remission in ulcerative colitis 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Selective prevention interventions vs control group

Adverse events at study endpoint · preventing mental disorders

2 findings from 1 review

Primary‐level and community worker interventions for the prevention of mental disorders and the promotion of… 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported
Primary‐level and community worker interventions for the prevention of mental disorders and the promotion of… 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Summary of findings table ‐ Indicated prevention interventions vs control group

Adverse events at study endpoint · preventing mental disorders

2 findings from 1 review

Primary‐level and community worker interventions for the prevention of mental disorders and the promotion of… 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Low
Primary‐level and community worker interventions for the prevention of mental disorders and the promotion of… 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Preoperative ibuprofen vs placebo

Adverse events · Children and adolescents having orthodontic separator placement (without local anaesthetic)

1 finding from 1 review

Preoperative analgesics for additional pain relief in children and adolescents having dental treatment 2016 · Cochrane All outcomes
One participant from the ibuprofen group and one from the placebo group reported a lip or cheek biting injury (Bernhardt 2001). No other adverse events were recorded for Bernhardt 2001 and Law 2000.
2 studies
GRADE not reported

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Adverse events at study endpoint · preventing mental disorders

2 findings from 1 review

Primary‐level and community worker interventions for the prevention of mental disorders and the promotion of… 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Low
Primary‐level and community worker interventions for the prevention of mental disorders and the promotion of… 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

'Other' antidepressants vs placebo

Adverse events · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 217 participants
Low

Tricylic antidepressant vs placebo

Adverse events (disease‐related: all physical symptoms); · chronic obstructive pulmonary disease (COPD) with depression

1 finding from 1 review

Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention

Adverse events—all‐cause mortality · type 1 or type 2 diabetics

1 finding from 1 review

Blood pressure control for diabetic retinopathy 2023 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Subacromial decompression vs exercise

Adverse events · people with impingement syndrome without full‐thickness rotator cuff tears

Subacromial decompression showed no clear difference in adverse events compared with exercises (moderate certainty).

1 finding from 1 review

Subacromial decompression surgery for rotator cuff disease 2019 · Cochrane Headline outcomes only
RR 0.91 [0.31, 2.65]
2 studies · 406 participants
Moderate

Subacromial decompression vs Placebo (sham/placebo device)

Adverse events · people with impingement syndrome without full‐thickness rotator cuff tears

Subacromial decompression showed no clear difference in adverse events compared with placebo surgery (moderate certainty).

1 finding from 1 review

Subacromial decompression surgery for rotator cuff disease 2019 · Cochrane Headline outcomes only
RR 0.91 [0.31, 2.65]
2 studies · 406 participants
Moderate

Pregabalin vs placebo

Serious adverse events · patients with chronic pancreatitis and pancreatic pain

Pregabalin showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Pregabalin for decreasing pancreatic pain in chronic pancreatitis 2016 · Cochrane Headline outcomes only
RR 1.76 [0.35, 8.96]
1 study · 64 participants
Low

Pregabalin vs placebo

Serious adverse events · adults with fibromyalgia enrolled in EERW studies

1 finding from 1 review

Pregabalin for pain in fibromyalgia in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 687 participants
Very low

Pregabalin vs placebo

Serious adverse events · adults with fibromyalgia

1 finding from 1 review

Pregabalin for pain in fibromyalgia in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1238 participants
Very low

Outcomes for all interventions for smoking cessation in pregnancy vs control: subgrouped by main intervention strategy (comparison 20)

Adverse events and psychological impact · Pregnant women who smoke

1 finding from 1 review

Psychosocial interventions for supporting women to stop smoking in pregnancy 2017 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 13 participants
High

Pressure‐garment therapy (PGT) vs silicone

Adverse events · people with burn wounds likely to develop hypertrophic scarring

1 finding from 1 review

Pressure‐garment therapy for preventing hypertrophic scarring after burn injury 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 159 participants
Very low