Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

59 questions · 59 findings · 23 reviews

No studies found 14 · 23.7%GRADE not reported 1 · 1.7%Very low 15 · 25.4%Low 14 · 23.7%Moderate 11 · 18.6%High 4 · 6.8%

Celecoxib vs tNSAIDs

Number withdrawn due to adverse events · patients with osteoarthritis

Celecoxib showed no clear difference in number withdrawn due to adverse events compared with tNSAIDs (low certainty).

1 finding from 1 review

Acupuncture vs NSAIDs

Number of participants reporting an adverse event · patients with hip osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Celecoxib vs tNSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether celecoxib changes number experiencing any serious adverse events compared with tNSAIDs (very low certainty).

1 finding from 1 review

Low‐dose colchicine vs NSAIDs

Number of participants reporting an adverse event · acute gout

Low‐dose colchicine showed no clear difference in total number of participants reporting adverse events compared with NSAIDs (low certainty).

1 finding from 1 review

Tramadol vs NSAIDs

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol alone may leads to higher number of participants who withdrew due to adverse events compared with NSAIDs (low certainty).

1 finding from 1 review

Tramadol vs NSAIDs

Number of participants experiencing any serious adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants experiencing any serious adverse events compared with NSAIDs (very low certainty).

1 finding from 1 review

Intervention not reported

Topical ketoprofen gel Local adverse events · adults with chronic musculoskeletal pain (osteoarthritis)
1 finding from 1 review

Intervention not reported

Topical diclofenac gel or solution Local adverse events · adults with chronic musculoskeletal pain (osteoarthritis)
1 finding from 1 review

Intervention not reported

Adverse events (Re‐operation for bleeding (reoperation for major bleeding within 30 days (yes/no))) · adults undergoing surgery

It is very uncertain whether the intervention changes adverse events (Re‐operation for bleeding (reoperation for major… (very low certainty).

1 finding from 1 review