What do systematic reviews say?

Four‐food elimination diet with omeprazole vs omeprazole

It is very uncertain whether four‐food elimination diet with omeprazole changes withdrawals due to adverse events at 8 to 12 weeks compared with omeprazole (very low certainty).

• Medical treatment of eosinophilic esophagitis 2023 · Cochrane Headline outcomes only
  RR 5 [0.62, 40.44]
  1 study · 64 participants
  Very low

Intervention not reported

• Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 632 participants
  Low

Pembrolizumab vs chemotherapy alone

Pembrolizumab may leads to lower serious adverse events (irrespective of attribution to treatment) compared with chemotherapy (low certainty).

• Pembrolizumab monotherapy versus chemotherapy for treatment of advanced urothelial carcinoma with disease progression… 2018 · Cochrane Headline outcomes only
  RR 0.83 [0.72, 0.97]
  1 study · 521 participants
  Low

Total or near‐total thyroidectomy vs subtotal thyroidectomy

Total or near‐total thyroidectomy showed no clear difference in adverse events: a) Permanent recurrent laryngeal nerve palsy b)… compared with subtotal thyroidectomy (low certainty).

• Total or near‐total thyroidectomy versus subtotal thyroidectomy for multinodular non‐toxic goitre in adults 2015 · Cochrane Headline outcomes only
  OR 1.28 [0.38, 4.36]
  4 studies · 1275 participants
  Low