Cochrane · systematic review · CD010370
Total or near‐total thyroidectomy versus subtotal thyroidectomy for multinodular non‐toxic goitre in adults
Cirocchi, R, Trastulli, S, Randolph, J, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
4
No studies
2
Included studies
NR
No studies 2 · 33.3%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Total or near‐total thyroidectomy compared with subtotal thyroidectomy for multinodular non‐toxic goitre in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Total or near‐total thyroidectomy vs subtotal thyroidectomy | no estimate extracted | 4 studies · 1284 participants | Moderate Downgraded: risk of bias, imprecision |
a)Goitre recurrence b)Re‐intervention due to goitre recurrence Total or near‐total thyroidectomy vs subtotal thyroidectomy | OR 0.05 [0.01, 0.21] | 3 studies · 1057 participants | Moderate Downgraded: risk of bias, imprecision |
Adverse events: a) Permanent recurrent laryngeal nerve palsy b) Permanent hypoparathyroidism Total or near‐total thyroidectomy vs subtotal thyroidectomy | OR 1.28 [0.38, 4.36] | 4 studies · 1275 participants | Low Downgraded: risk of bias, imprecision |
Thyroid cancer incidence Total or near‐total thyroidectomy vs subtotal thyroidectomy | OR 1.32 [0.81, 2.15] | 3 studies · 1134 participants | Low Downgraded: risk of bias, imprecision |
Health‐related quality of life Total or near‐total thyroidectomy vs subtotal thyroidectomy | no estimate extracted | NR | No studies |
Socioeconomic effects Total or near‐total thyroidectomy vs subtotal thyroidectomy | no estimate extracted | NR | No studies |