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Evidence found and GRADE certainty

50 questions · 51 findings · 24 reviews

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No studies found 14 · 27.5%GRADE not reported 2 · 3.9%Very low 13 · 25.5%Low 12 · 23.5%Moderate 9 · 17.6%High 1 · 2%

TNF‐α blockers intervention vs placebo or additional treatment

Adverse effects: contact dermatitis · children diagnosed with Kawasaki disease

It is very uncertain whether TNF‐α blockers intervention changes adverse effects after treatment initiation: cutaneous reactions… compared with placebo or additional treatment (very low certainty).

1 finding from 1 review

Vigabatrin vs placebo

Adverse effects: dizziness, lightheadedness · people (aged 10–64 years) with drug‐resistant focal epilepsy

Vigabatrin may leads to higher adverse effects: dizziness/light‐headedness Duration of treatment… compared with placebo (low certainty).

1 finding from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes leaving the study early due to adverse effects (overall tolerability… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Antibiotics vs placebo compared

Adverse effects of antibiotics · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze

Antibiotic therapy showed no clear difference in treatment harms (adverse events or side effects associated with… compared with placebo compared to placebo (low certainty).

1 finding from 1 review

Benzoyl peroxide vs placebo or no treatment

Adverse effects (side effects; treatment withdrawals) · participants with acne

Benzoyl peroxide may leads to higher withdrawal due to adverse effects (long‐term data) Treatment… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Memantine vs placebo

Adverse effects sufficient to stop treatment · Children aged 6 to 18 years with ASD

Memantine showed no clear difference in adverse effects Assessed by the study authors as those that were… compared with placebo (low certainty).

1 finding from 1 review

TNF‐α blockers intervention vs placebo or additional treatment

Adverse effects after treatment initiation: injection site reactions, neutropenia, infections, demyelinating disease, heart failure, malignancy, and induction of autoimmunity. · children diagnosed with Kawasaki disease

The review found no eligible studies for this question.

1 finding from 1 review