Findings

What do systematic reviews say?

6 questions · 6 findings · 4 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

BENZODIAZEPINES AS SOLE TREATMENT vs placebo

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

1 finding from 1 review

Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 161 participants
Very low

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes leaving the study early due to adverse effects (overall tolerability… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
RR 3.24 [0.68, 15.45]
6 studies · 415 participants
Very low

VIDEO GAMES (COMMERCIAL NON‐EXERGAMES) (plus standard care) vs COGNITIVE REMEDIATION (plus standard care)

Adverse effects*: leaving the study early ‐ did not leave · patients with schizophrenia

VIDEO GAMES (COMMERCIAL NON‐EXERGAMES) (plus standard care) showed no clear difference in adverse effects*: leaving the study early ‐ did not leave ‐ by end… compared with COGNITIVE REMEDIATION (plus standard care) (low certainty).

1 finding from 1 review

Video games for people with schizophrenia 2021 · Cochrane Headline outcomes only
RR 0.96 [0.87, 1.06]
5 studies · 395 participants
Low

Benzodiazepines vs antipsychotics

Adverse effects (drop‐outs due to adverse effects4) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to adverse effects (overall tolerability… compared with ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
RR 13 [0.78, 216.39]
5 studies · 444 participants
Very low

Extended specialised early intervention (SEI) teams vs standard SEI teams plus treatment

Adverse effects/events: death ‐ all‐cause mortality(assessed by patient records) · recent‐onset psychosis

Extended specialised early intervention (SEI) teams showed no clear difference in adverse effects/events: death ‐ all‐cause mortality(assessed by… compared with standard SEI teams plus treatment (low certainty).

1 finding from 1 review

Specialised early intervention teams (extended time) for recent‐onset psychosis 2020 · Cochrane Headline outcomes only
RR 0.38 [0.09, 1.64]
3 studies · 780 participants
Low

TEMPOROPARIETAL TMS vs usual care

Adverse effects: Leaving the study early · patients with schizophrenia

It is very uncertain whether TEMPOROPARIETAL TMS changes adverse effects: Leaving the study early compared with STANDARD TREATMENT (very low certainty).

1 finding from 1 review

Transcranial magnetic stimulation (TMS) for schizophrenia 2015 · Cochrane Headline outcomes only
RR 0.33 [0.08, 1.46]
2 studies · 140 participants
Very low